Home Iodos 128719-90-4
128719-90-4,MFCD00084824
Catalog No.:AA009AJ4

128719-90-4 | 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID

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1mg
≥95%
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$860.00   $602.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA009AJ4
Chemical Name:
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
CAS Number:
128719-90-4
Molecular Formula:
C23H29IO5
Molecular Weight:
512.3778
MDL Number:
MFCD00084824
SMILES:
OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@@H]1/C=C/[C@H](COc1ccc(cc1)I)O)O2
Properties
Computed Properties
 
Complexity:
570  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
11  
XLogP3:
4  

Literature

Title: Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells.

Journal: Current cancer drug targets 20120701

Title: Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110101

Title: Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells.

Journal: Lung cancer (Amsterdam, Netherlands) 20100701

Title: Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells.

Journal: Carcinogenesis 20090901

Title: Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling.

Journal: The Journal of biological chemistry 20090619

Title: Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species.

Journal: Journal of lipid research 20090601

Title: TP receptor-mediated release of eosinophil chemotactic activity from human bronchial smooth muscle cells.

Journal: European journal of pharmacology 20081214

Title: Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide.

Journal: Circulation research 20080215

Title: F2-isoprostanes are not just markers of oxidative stress.

Journal: Free radical biology & medicine 20080201

Title: F2-isoprostane receptors on hepatic stellate cells.

Journal: Laboratory investigation; a journal of technical methods and pathology 20080201

Title: Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells.

Journal: Archives of biochemistry and biophysics 20071101

Title: Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells.

Journal: Biochemical pharmacology 20070901

Title: Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells.

Journal: Biochemical and biophysical research communications 20061229

Title: Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation, and cell morphology change following stimulation of thromboxane receptor alpha.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Human bronchial smooth muscle cell proliferation via thromboxane A2 receptor.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20041201

Title: Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration.

Journal: Circulation research 20040820

Title: Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3.

Journal: Circulation research 20040402

Title: Glibenclamide inhibits thromboxane-mediated vasoconstriction by thromboxane receptor blockade.

Journal: Vascular pharmacology 20040101

Title: Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.

Journal: Blood 20030215

Title: A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt.

Journal: American journal of physiology. Heart and circulatory physiology 20020101

Title: Changes in vascular responsiveness to a thromboxane mimetic in endotoxin tolerance.

Journal: Shock (Augusta, Ga.) 20011101

Title: Serine 331 is the major site of receptor phosphorylation induced by agents that activate protein kinase G in HEK 293 cells overexpressing thromboxane receptor alpha.

Journal: Archives of biochemistry and biophysics 20010901

Title: Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.

Journal: British journal of pharmacology 19970901

Title: Characterization of the prostanoid TP receptor population in human nonpregnant myometrium.

Journal: The Journal of pharmacology and experimental therapeutics 19961001

Title: 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19920801

Title: Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets.

Journal: The Journal of biological chemistry 19910725

Title: Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist.

Journal: The Journal of pharmacology and experimental therapeutics 19891101

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Tags:128719-90-4 Molecular Formula|128719-90-4 MDL|128719-90-4 SMILES|128719-90-4 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID