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1222780-33-7,MFCD26142949
Catalog No.:AA009BM9

1222780-33-7 | TPPU

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$22.00   $15.00
- +
5mg
98%
in stock  
$63.00   $44.00
- +
10mg
98%
in stock  
$121.00   $85.00
- +
25mg
98%
in stock  
$247.00   $173.00
- +
50mg
98%
in stock  
$363.00   $254.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009BM9
Chemical Name:
TPPU
CAS Number:
1222780-33-7
Molecular Formula:
C16H20F3N3O3
Molecular Weight:
359.3435
MDL Number:
MFCD26142949
SMILES:
CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)OC(F)(F)F
Properties
Computed Properties
 
Complexity:
457  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Rose,TristanE.;Morisseau,Christophe;Liu,Jun-Yan;Inceoglu,Bora;Jones,PaulD.;Sanborn,JamesR.;Hammock,BruceD.[JournalofMedicinalChemistry,2010,vol.53,#19,p.7067-7075]

[2]CurrentPatentAssignee:UNIVERSITYOFCALIFORNIA-US9296693,2016,B2Locationinpatent:Page/Pagecolumn43

[1]CurrentPatentAssignee:UNIVERSITYOFCALIFORNIA-US9296693,2016,B2

Literature

Title: 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.

Journal: Journal of medicinal chemistry 20101014

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Ulu A, et al. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br J Pharmacol. 2012 Mar;165(5):1401-12.

Title: Ostermann AI, et al. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3--(trifluoromethoxy)phenylurea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):131-7.

Title: Ren Q, et al. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America (2016), 113(13), E1944-E1952.

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