Home Other Building Blocks 1357160-72-5
1357160-72-5,MFCD22987960
Catalog No.:AA009BMA

1357160-72-5 | URB937

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Purity
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5mg
≥95%
in stock  
$58.00   $40.00
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10mg
≥95%
in stock  
$109.00   $76.00
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50mg
≥95%
in stock  
$446.00   $312.00
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100mg
≥95%
in stock  
$779.00   $545.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009BMA
Chemical Name:
URB937
CAS Number:
1357160-72-5
Molecular Formula:
C20H22N2O4
Molecular Weight:
354.3997
MDL Number:
MFCD22987960
SMILES:
O=C(Oc1ccc(c(c1)c1cccc(c1)C(=O)N)O)NC1CCCCC1
Properties
Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
3.5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:UNIVERSITYOFPARMA;UNIVERSITYOFCALIFORNIA;GUIDUCCIGIOVANNA;UNIVERSITYOFURBINO-WO2012/15704,2012,A2

Literature

Title: Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.

Journal: Pharmacological research 20120501

Title: The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system.

Journal: Pharmacological research 20111001

Title: Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

Journal: Nature neuroscience 20101001

Title: Jason R Clapper, et al. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 2010 Oct;13(10):1265-70.

Title: Valentina Vozella, et al. Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor, in rats. J Pharm Pharmacol. 2019 Dec;71(12):1762-1773.

Title: G Moreno-Sanz, et al. Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. Br J Pharmacol. 2012 Dec;167(8):1620-8.

Title: Rui Li, et al. The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model. Inflammation. 2017 Aug;40(4):1254-1263.

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SDS
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