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1356962-20-3,MFCD25976759
Catalog No.:AA009C6E

1356962-20-3 | ALK/IGF1R inhibitor

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
95%
in stock  
$198.00   $139.00
- +
50mg
95%
in stock  
$484.00   $339.00
- +
100mg
95%
in stock  
$833.00   $583.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009C6E
Chemical Name:
ALK/IGF1R inhibitor
CAS Number:
1356962-20-3
Molecular Formula:
C24H25ClN6O
Molecular Weight:
448.9479
MDL Number:
MFCD25976759
SMILES:
COc1cc(ccc1Nc1ncc(c(n1)c1c[nH]c2c1cccc2)Cl)N1CCC(CC1)N
Properties
Computed Properties
 
Complexity:
605  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2012/28924,2012,A1Locationinpatent:Page/Pagecolumn39

Literature

Title: Lisa Drew, et al. Abstract 919: AZD3463, a novel ALK/IGF1R inhibitor, overcomes multiple mechanisms of acquired resistance to crizotinib. Cancer Res 2013;73.

Title: Yongfeng Wang, et al. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016; 6: 19423.

Title: Sausan A. Moharram, et al. The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia. Blood Cancer J. 2019 Feb; 9(2): 5.

Quotation Request
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SDS
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Tags:1356962-20-3 Molecular Formula|1356962-20-3 MDL|1356962-20-3 SMILES|1356962-20-3 ALK/IGF1R inhibitor
Catalog No.: AA009C6E
1356962-20-3,MFCD25976759
1356962-20-3 | ALK/IGF1R inhibitor
Pack Size： 1mg
Purity： ≥98%
in stock
$46.00 $32.00
Pack Size： 5mg
Purity： ≥98%
in stock
$156.00 $109.00
Pack Size： 10mg
Purity： 95%
in stock
$198.00 $139.00
Pack Size： 50mg
Purity： 95%
in stock
$484.00 $339.00
Pack Size： 100mg
Purity： 95%
in stock
$833.00 $583.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA009C6E
Chemical Name: ALK/IGF1R inhibitor
CAS Number: 1356962-20-3
Molecular Formula: C24H25ClN6O
Molecular Weight: 448.9479
MDL Number: MFCD25976759
SMILES: COc1cc(ccc1Nc1ncc(c(n1)c1c[nH]c2c1cccc2)Cl)N1CCC(CC1)N
Properties
Complexity: 605  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.2  
Downstream Synthesis Route
937366-57-9    1356963-24-0    1356962-20-3 

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2012/28924,2012,A1Locationinpatent:Page/Pagecolumn39

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