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Home Quinolines 1345675-02-6
1345675-02-6,MFCD23160051
Catalog No.:AA009C8W

1345675-02-6 | 2-methyl-2-{4-[2-oxo-9-(quinolin-3-yl)-4H-[1,3]oxazino[5,4-c]quinolin-1-yl]phenyl}propanenitrile

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$192.00   $134.00
- +
10mg
98% by HPLC
in stock  
$322.00   $225.00
- +
25mg
98%
in stock  
$593.00   $415.00
- +
50mg
98%
in stock  
$843.00   $590.00
- +
100mg
98%
in stock  
$1,307.00   $915.00
- +
500mg
98% by HPLC
in stock  
$5,256.00   $3,679.00
- +
1000mg
98% by HPLC
in stock  
$8,372.00   $5,860.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009C8W
Chemical Name:
2-methyl-2-{4-[2-oxo-9-(quinolin-3-yl)-4H-[1,3]oxazino[5,4-c]quinolin-1-yl]phenyl}propanenitrile
CAS Number:
1345675-02-6
Molecular Formula:
C30H22N4O2
Molecular Weight:
470.5213
MDL Number:
MFCD23160051
SMILES:
N#CC(c1ccc(cc1)N1C(=O)OCc2c1c1cc(ccc1nc2)c1cnc2c(c1)cccc2)(C)C
Properties
Computed Properties
 
Complexity:
858  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
3  
XLogP3:
5.6  

Literature

Title: A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

Journal: Nature structural & molecular biology 20110601

Title: Toledo LI, et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18(6):721-7.

Title: Teng PN, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136(3):554-61.

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SDS
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Tags:1345675-02-6 Molecular Formula|1345675-02-6 MDL|1345675-02-6 SMILES|1345675-02-6 2-methyl-2-{4-[2-oxo-9-(quinolin-3-yl)-4H-[1,3]oxazino[5,4-c]quinolin-1-yl]phenyl}propanenitrile