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1351761-44-8,MFCD25977005
Catalog No.:AA009C92

1351761-44-8 | Gne-7915

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$43.00   $30.00
- +
10mg
98%
in stock  
$67.00   $47.00
- +
100mg
95%
in stock  
$137.00   $96.00
- +
250mg
95%
in stock  
$311.00   $218.00
- +
1g
95%
in stock  
$917.00 $642.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009C92
Chemical Name:
Gne-7915
CAS Number:
1351761-44-8
Molecular Formula:
C19H21F4N5O3
Molecular Weight:
443.3954
MDL Number:
MFCD25977005
SMILES:
CCNc1nc(ncc1C(F)(F)F)Nc1cc(F)c(cc1OC)C(=O)N1CCOCC1
Properties
Computed Properties
 
Complexity:
593  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.8  

Literature

Title: Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Journal: Journal of medicinal chemistry 20140213

Title: The development of CNS-active LRRK2 inhibitors using property-directed optimisation.

Journal: Bioorganic & medicinal chemistry letters 20130701

Title: Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Journal: Journal of medicinal chemistry 20121126

Title: Kavanagh ME, et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett.?2013 Jul 1;23(13):3690-6.

Title: Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.

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SDS
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Tags:1351761-44-8 Molecular Formula|1351761-44-8 MDL|1351761-44-8 SMILES|1351761-44-8 Gne-7915
Catalog No.: AA009C92
1351761-44-8,MFCD25977005
1351761-44-8 | Gne-7915
Pack Size： 5mg
Purity： 98%
in stock
$43.00 $30.00
Pack Size： 10mg
Purity： 98%
in stock
$67.00 $47.00
Pack Size： 100mg
Purity： 95%
in stock
$137.00 $96.00
Pack Size： 250mg
Purity： 95%
in stock
$311.00 $218.00
Pack Size： 1g
Purity： 95%
in stock
$917.00 $642.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA009C92
Chemical Name: Gne-7915
CAS Number: 1351761-44-8
Molecular Formula: C19H21F4N5O3
Molecular Weight: 443.3954
MDL Number: MFCD25977005
SMILES: CCNc1nc(ncc1C(F)(F)F)Nc1cc(F)c(cc1OC)C(=O)N1CCOCC1
Properties
Complexity: 593  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 6  
XLogP3: 2.8  
Literature fold

Title: Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Journal: Journal of medicinal chemistry20140213

Title: The development of CNS-active LRRK2 inhibitors using property-directed optimisation.

Journal: Bioorganic & medicinal chemistry letters20130701

Title: Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Journal: Journal of medicinal chemistry20121126

Title: Kavanagh ME, et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett.?2013 Jul 1;23(13):3690-6.

Title: Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33.

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