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1227911-45-6,MFCD21608525
Catalog No.:AA009C98

1227911-45-6 | Gsk2334470

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$23.00   $16.00
- +
5mg
98%
in stock  
$54.00   $38.00
- +
10mg
98%
in stock  
$71.00   $50.00
- +
1000mg
99% (HPLC)
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009C98
Chemical Name:
Gsk2334470
CAS Number:
1227911-45-6
Molecular Formula:
C25H34N8O
Molecular Weight:
462.5905
MDL Number:
MFCD21608525
SMILES:
CNc1nc(cc(n1)c1ccc2c(c1)[nH]nc2N)N1C[C@H](CC[C@H]1C)C(=O)NC1CCCCC1
Properties
Computed Properties
 
Complexity:
688  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
3.9  

Literature

Title: Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).

Journal: Journal of medicinal chemistry 20111222

Title: Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.

Journal: Journal of medicinal chemistry 20110324

Title: Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

Journal: The Biochemical journal 20110115

Title: For a PDK1 inhibitor, the substrate matters.

Journal: The Biochemical journal 20110115

Title: Structure, regulation and function of PKB/AKT--a major therapeutic target.

Journal: Biochimica et biophysica acta 20040311

Title: Role of Akt signaling in vascular homeostasis and angiogenesis.

Journal: Circulation research 20020628

Title: Najafov A, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J.?2011 Jan 15;433(2):357-69.

Title: Qi L, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int.?2015 Sep 29;15:91.

Title: Scortegagna M, et al. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9.

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SDS
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