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1337532-29-2,MFCD27997885
Catalog No.:AA009C9C

1337532-29-2 | Gsk2656157

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$38.00   $27.00
- +
5mg
≥98%
in stock  
$68.00   $47.00
- +
10mg
≥98%
in stock  
$125.00   $87.00
- +
25mg
98%
in stock  
$267.00   $187.00
- +
50mg
≥98%
in stock  
$515.00   $360.00
- +
100mg
98%
in stock  
$743.00   $520.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009C9C
Chemical Name:
Gsk2656157
CAS Number:
1337532-29-2
Molecular Formula:
C23H21FN6O
Molecular Weight:
416.4508
MDL Number:
MFCD27997885
SMILES:
O=C(N1CCc2c1ccc(c2F)c1cn(c2c1c(N)ncn2)C)Cc1cccc(n1)C
Properties
Computed Properties
 
Complexity:
666  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.3  

Literature

Title: Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.

Journal: ACS medicinal chemistry letters 20131010

Title: Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.

Journal: Cancer research 20130315

Title: Atkins C, et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2013 Mar 15;73(6):1993-2002.

Title: Krishnamoorthy J, et al. Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications. Cell Cycle. 2014 Mar 1;13(5):801-6.

Title: Ando T, et al. GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells. Immunopharmacol Immunotoxicol. 2016 Aug;38(4):298-302.

Title: Zhao Q, et al. Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage. J Neuroinflammation. 2017 May 11;14(1):104.

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SDS
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Tags:1337532-29-2 Molecular Formula|1337532-29-2 MDL|1337532-29-2 SMILES|1337532-29-2 Gsk2656157
Catalog No.: AA009C9C
1337532-29-2,MFCD27997885
1337532-29-2 | Gsk2656157
Pack Size： 1mg
Purity： 98%
in stock
$38.00 $27.00
Pack Size： 5mg
Purity： ≥98%
in stock
$68.00 $47.00
Pack Size： 10mg
Purity： ≥98%
in stock
$125.00 $87.00
Pack Size： 25mg
Purity： 98%
in stock
$267.00 $187.00
Pack Size： 50mg
Purity： ≥98%
in stock
$515.00 $360.00
Pack Size： 100mg
Purity： 98%
in stock
$743.00 $520.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA009C9C
Chemical Name: Gsk2656157
CAS Number: 1337532-29-2
Molecular Formula: C23H21FN6O
Molecular Weight: 416.4508
MDL Number: MFCD27997885
SMILES: O=C(N1CCc2c1ccc(c2F)c1cn(c2c1c(N)ncn2)C)Cc1cccc(n1)C
Properties
Complexity: 666  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 3  
XLogP3: 2.3  
Literature fold

Title: Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.

Journal: ACS medicinal chemistry letters20131010

Title: Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.

Journal: Cancer research20130315

Title: Atkins C, et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2013 Mar 15;73(6):1993-2002.

Title: Krishnamoorthy J, et al. Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications. Cell Cycle. 2014 Mar 1;13(5):801-6.

Title: Ando T, et al. GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells. Immunopharmacol Immunotoxicol. 2016 Aug;38(4):298-302.

Title: Zhao Q, et al. Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage. J Neuroinflammation. 2017 May 11;14(1):104.

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