Home Other Building Blocks 1373423-53-0
1373423-53-0,MFCD22683852
Catalog No.:AA009C9F

1373423-53-0 | Gsk-j4

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5mg
98% by HPLC
in stock  
$179.00   $125.00
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10mg
98% by HPLC
in stock  
$258.00   $180.00
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25mg
98% by HPLC
in stock  
$473.00   $331.00
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50mg
98% by HPLC
in stock  
$761.00   $533.00
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100mg
98% by HPLC
in stock  
$1,270.00   $889.00
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500mg
98% by HPLC
in stock  
$3,958.00   $2,771.00
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1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009C9F
Chemical Name:
Gsk-j4
CAS Number:
1373423-53-0
Molecular Formula:
C24H27N5O2
Molecular Weight:
417.5035
MDL Number:
MFCD22683852
SMILES:
CCOC(=O)CCNc1cc(nc(n1)c1ccccn1)N1CCc2c(CC1)cccc2
Properties
Computed Properties
 
Complexity:
546  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
4.3  

Literature

Title: Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

Journal: The Journal of biological chemistry 20180216

Title: Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20160201

Title: Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Journal: Nature 20141023

Title: Inhibition of demethylases by GSK-J1/J4.

Journal: Nature 20141002

Title: Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Journal: Nature communications 20140101

Title: A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Journal: Nature 20120816

Title: Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8.

Title: Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499.

Title: Donas C, et al. The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. J Autoimmun. 2016 Dec;75:105-117.

Title: Yapp C, et al. H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis. Arthritis Res Ther. 2016 Jul 7;18(1):158

Title: Kamikawa YF, et al. Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. PLoS One. 2015 May 20;10(5):e0125626

Title: Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2

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