Name: Name:3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol
Brand: AABLOCKS
SKU: AA009C9Q
Rating: 90 (10 reviews)

Catalog No.: AA009C9Q

1431985-92-0 | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol

Pack Size： 1mg

Purity： 98%

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$7.00 $5.00

Pack Size： 10mg

Purity： 98%

in stock

$14.00 $10.00

Pack Size： 50mg

Purity： 98%

in stock

$54.00 $38.00

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Technical Information

Catalog Number: AA009C9Q

Chemical Name: 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol

CAS Number: 1431985-92-0

Molecular Formula: C20H20N2O4

Molecular Weight: 352.3838

MDL Number: MFCD26936347

SMILES: COc1cc(cc(c1OC)OC)c1cc(cnc1N)c1cccc(c1)O

Properties

Complexity: 424

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 26

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 5

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.3

Downstream Synthesis Route

381233-96-1

1431985-92-0

[1]Mohedas,AgustinH.;Wang,You;Sanvitale,CarolineE.;Canning,Peter;Choi,Sungwoon;Xing,Xuechao;Bullock,AlexN.;Cuny,GregoryD.;Yu,PaulB.[JournalofMedicinalChemistry,2014,vol.57,#19,p.7900-7915]

[2]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2015/148654,2015,A1

[3]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2016/54406,2016,A1

1627503-64-3

87199-18-6

1431985-92-0

[1]Mohedas,AgustinH.;Wang,You;Sanvitale,CarolineE.;Canning,Peter;Choi,Sungwoon;Xing,Xuechao;Bullock,AlexN.;Cuny,GregoryD.;Yu,PaulB.[JournalofMedicinalChemistry,2014,vol.57,#19,p.7900-7915]

[2]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2015/148654,2015,A1Locationinpatent:Page/Pagecolumn45

[3]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2016/54406,2016,A1Locationinpatent:Page/Pagecolumn52

182163-96-8

1431985-92-0

[1]Mohedas,AgustinH.;Wang,You;Sanvitale,CarolineE.;Canning,Peter;Choi,Sungwoon;Xing,Xuechao;Bullock,AlexN.;Cuny,GregoryD.;Yu,PaulB.[JournalofMedicinalChemistry,2014,vol.57,#19,p.7900-7915]

[2]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2015/148654,2015,A1

[3]CurrentPatentAssignee:MASSGENERALBRIGHAMINC-WO2016/54406,2016,A1

1450754-37-6

1431985-92-0

CASUnavailable

[1]Tong,Yuquan;Gibaut,QuentinM.R.;Rouse,Warren;Childs-Disney,JessicaL.;Suresh,BlessyM.;Abegg,Daniel;Choudhary,Shruti;Akahori,Yoshihiro;Adibekian,Alexander;Moss,WalterN.;Disney,MatthewD.[JournaloftheAmericanChemicalSociety,2022,vol.144,#26,p.11620-11625]

Literature fold

Title: Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.

Journal: Journal of medicinal chemistry20141009

Title: Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721.

Title: Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17.