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1234480-84-2,MFCD22683805
Catalog No.:AA009CA1

1234480-84-2 | Lrrk2-in-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$29.00   $21.00
- +
10mg
98%
in stock  
$45.00   $32.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CA1
Chemical Name:
Lrrk2-in-1
CAS Number:
1234480-84-2
Molecular Formula:
C31H38N8O3
Molecular Weight:
570.6852
MDL Number:
MFCD22683805
SMILES:
COc1cc(ccc1Nc1ncc2c(n1)n(C)c1ccccc1c(=O)n2C)C(=O)N1CCC(CC1)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
939  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3  

Literature

Title: The development of CNS-active LRRK2 inhibitors using property-directed optimisation.

Journal: Bioorganic & medicinal chemistry letters 20130701

Title: Brain Penetrant LRRK2 Inhibitor.

Journal: ACS medicinal chemistry letters 20120809

Title: Characterization of TAE684 as a potent LRRK2 kinase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20120301

Title: Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Journal: Nature chemical biology 20110401

Title: Hermanson SB, et al. Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation.PLoS One. 2012;7(8):e43580. Epub 2012 Aug 28.

Title: Deng, Xianming., et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology (2011), 7(4), 203-205.

Title: Koshibu K, et al. Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease. Pharmacology. 2015;96(5-6):240-7.

Title: Weygant N, et al. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 6;13:103.

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