Title: The development of CNS-active LRRK2 inhibitors using property-directed optimisation.
Journal: Bioorganic & medicinal chemistry letters 20130701
Title: Brain Penetrant LRRK2 Inhibitor.
Journal: ACS medicinal chemistry letters 20120809
Title: Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20120301
Title: Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Journal: Nature chemical biology 20110401
Title: Hermanson SB, et al. Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation.PLoS One. 2012;7(8):e43580. Epub 2012 Aug 28.
Title: Deng, Xianming., et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology (2011), 7(4), 203-205.
Title: Koshibu K, et al. Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease. Pharmacology. 2015;96(5-6):240-7.
Title: Weygant N, et al. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 6;13:103.