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1255517-76-0,MFCD18086922
Catalog No.:AA009CBD

1255517-76-0 | Pf-4708671

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$19.00   $14.00
- +
5mg
98%
in stock  
$46.00   $32.00
- +
10mg
98%
in stock  
$68.00   $48.00
- +
50mg
98%
in stock  
$192.00   $135.00
- +
1000mg
DMSO
in stock  
$3,803.00   $2,662.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009CBD
Chemical Name:
Pf-4708671
CAS Number:
1255517-76-0
Molecular Formula:
C19H21F3N6
Molecular Weight:
390.4054
MDL Number:
MFCD18086922
SMILES:
CCc1cncnc1N1CCN(CC1)Cc1nc2c([nH]1)cc(cc2)C(F)(F)F
Properties
Computed Properties
 
Complexity:
510  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.2  

Upstream Synthesis Route

[1]BiochemicalJournal,2010,vol.431,#2,p.245-255

[1]BiochemicalJournal,2010,vol.431,#2,p.245-255

Downstream Synthesis Route

[1]BiochemicalJournal,2010,vol.431,p.245-255

Literature

Title: S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.

Journal: Toxicology letters 20150304

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.

Journal: Amino acids 20120601

Title: S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

Journal: The Biochemical journal 20120101

Title: Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Journal: The Biochemical journal 20101015

Title: Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.

Title: Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809.

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SDS
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Tags:1255517-76-0 Molecular Formula|1255517-76-0 MDL|1255517-76-0 SMILES|1255517-76-0 Pf-4708671
Catalog No.: AA009CBD
1255517-76-0,MFCD18086922
1255517-76-0 | Pf-4708671
Pack Size： 1mg
Purity： 98%
in stock
$19.00 $14.00
Pack Size： 5mg
Purity： 98%
in stock
$46.00 $32.00
Pack Size： 10mg
Purity： 98%
in stock
$68.00 $48.00
Pack Size： 50mg
Purity： 98%
in stock
$192.00 $135.00
Pack Size： 1000mg
Purity： DMSO
in stock
$3,803.00 $2,662.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA009CBD
Chemical Name: Pf-4708671
CAS Number: 1255517-76-0
Molecular Formula: C19H21F3N6
Molecular Weight: 390.4054
MDL Number: MFCD18086922
SMILES: CCc1cncnc1N1CCN(CC1)Cc1nc2c([nH]1)cc(cc2)C(F)(F)F
Properties
Complexity: 510  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 4  
XLogP3: 3.2  
Upstream Synthesis Route
1256492-23-5    107430-29-5    1255517-76-0 

[1]BiochemicalJournal,2010,vol.431,#2,p.245-255

25198-98-5    1255517-76-0 

[1]BiochemicalJournal,2010,vol.431,#2,p.245-255

Downstream Synthesis Route
1256492-23-5    107430-29-5    1255517-76-0 

[1]BiochemicalJournal,2010,vol.431,p.245-255

Literature fold

Title: S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.

Journal: Toxicology letters20150304

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.

Journal: Amino acids20120601

Title: S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

Journal: The Biochemical journal20120101

Title: Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Journal: The Biochemical journal20101015

Title: Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.

Title: Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809.

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