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Home Amines 1214265-58-3
1214265-58-3,MFCD28015100
Catalog No.:AA009CCW

1214265-58-3 | N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
98+%
in stock  
$89.00   $62.00
- +
10mg
98+%
in stock  
$125.00   $88.00
- +
25mg
98+%
in stock  
$178.00   $125.00
- +
50mg
98+%
in stock  
$253.00   $178.00
- +
100mg
98+%
in stock  
$364.00   $255.00
- +
250mg
98+%
in stock  
$558.00   $390.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CCW
Chemical Name:
N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide
CAS Number:
1214265-58-3
Molecular Formula:
C25H29ClN6O3
Molecular Weight:
496.9892
MDL Number:
MFCD28015100
SMILES:
CCC(=O)Nc1cccc(c1)Oc1nc(ncc1Cl)Nc1ccc(cc1OC)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
667  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4.1  

Literature

Title: Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8.

Journal: Journal of cellular and molecular medicine 20170701

Title: Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

Journal: The Biochemical journal 20140715

Title: Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.

Journal: The Biochemical journal 20140101

Title: Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.

Title: Zhou W, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24;462(7276):1070-4

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SDS
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Tags:1214265-58-3 Molecular Formula|1214265-58-3 MDL|1214265-58-3 SMILES|1214265-58-3 N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide