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1354037-26-5,MFCD20926346
Catalog No.:AA009CFV

1354037-26-5 | KH CB19

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98% by HPLC
in stock  
$170.00   $119.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009CFV
Chemical Name:
KH CB19
CAS Number:
1354037-26-5
Molecular Formula:
C15H13Cl2N3O2
Molecular Weight:
338.1886
MDL Number:
MFCD20926346
SMILES:
CCOC(=O)c1c(/C(=C\N)/C#N)c2c(n1C)c(Cl)c(cc2)Cl
Properties
Computed Properties
 
Complexity:
516  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.1  

Literature

Title: Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.

Journal: Bioorganic & medicinal chemistry letters 20130615

Title: Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.

Journal: Biochimica et biophysica acta 20110801

Title: Kinase inhibition that hinges on halogen bonds.

Journal: Chemistry & biology 20110128

Title: Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Journal: Chemistry & biology 20110128

Title: Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76.

Title: Grant SK, et al. Kinase inhibition that hinges on halogen bonds. Chem Biol. 2011 Jan 28;18(1):3-4.

Title: Jain P, et al. Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease. Curr Drug Targets. 2014;15(5):539-550.

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Tags:1354037-26-5 Molecular Formula|1354037-26-5 MDL|1354037-26-5 SMILES|1354037-26-5 KH CB19
Catalog No.: AA009CFV
1354037-26-5,MFCD20926346
1354037-26-5 | KH CB19
Pack Size： 1mg
Purity： 98% by HPLC
in stock
$170.00 $119.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA009CFV
Chemical Name: KH CB19
CAS Number: 1354037-26-5
Molecular Formula: C15H13Cl2N3O2
Molecular Weight: 338.1886
MDL Number: MFCD20926346
SMILES: CCOC(=O)c1c(/C(=C\N)/C#N)c2c(n1C)c(Cl)c(cc2)Cl
Properties
Complexity: 516  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 22  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.1  
Literature fold

Title: Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.

Journal: Bioorganic & medicinal chemistry letters20130615

Title: Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.

Journal: Biochimica et biophysica acta20110801

Title: Kinase inhibition that hinges on halogen bonds.

Journal: Chemistry & biology20110128

Title: Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Journal: Chemistry & biology20110128

Title: Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76.

Title: Grant SK, et al. Kinase inhibition that hinges on halogen bonds. Chem Biol. 2011 Jan 28;18(1):3-4.

Title: Jain P, et al. Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease. Curr Drug Targets. 2014;15(5):539-550.

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