Catalog No.:AA009CGU

1225037-39-7 | 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

Name: Name:5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
Brand: AABLOCKS
SKU: AA009CGU
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1mg

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$17.00 $12.00

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5mg

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$44.00 $31.00

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25mg

97%

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$173.00 $121.00

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100mg

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$420.00 $294.00

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97%

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA009CGU

Chemical Name:

5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

CAS Number:

1225037-39-7

Molecular Formula:

C17H20F3N7O2

Molecular Weight:

411.3816

MDL Number:

MFCD28902193

SMILES:

N=c1[nH]cc(c(c1)C(F)(F)F)c1nc(nc(n1)N1CCOCC1)N1CCOCC1

Properties

Computed Properties

Complexity:

506

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.3

Literature

Title: Conformationally restricted analogs of histamine H1 receptor antagonists: trans and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine.

Journal: Journal of medicinal chemistry 19760101

Title: Beaufils F, et al. 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J Med Chem. 2017 Sep 14;60(17):7524-7538.

Title: Wicki A, et al. First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13). Eur J Cancer. 2018 Jun;96:6-16.

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