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Home Other Building Blocks 1260075-17-9
1260075-17-9,MFCD26936342
Catalog No.:AA009CGX

1260075-17-9 | Pkr-in-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$234.00   $164.00
- +
25mg
99%
in stock  
$765.00   $535.00
- +
50mg
98%
in stock  
$906.00   $634.00
- +
100mg
98%
in stock  
$1,436.00   $1,005.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CGX
Chemical Name:
Pkr-in-1
CAS Number:
1260075-17-9
Molecular Formula:
C24H26N4O3S
Molecular Weight:
450.5532
MDL Number:
MFCD26936342
SMILES:
O=C(c1ccc(cc1)NS(=O)(=O)c1cccc2c1nccc2)N1CCN(CC1)CC1CC1
Properties
Computed Properties
 
Complexity:
750  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
1.8  

Downstream Synthesis Route
116834-64-1   
1-(cyclopropylmethyl)piperazinedihydrochloride 
  1260075-17-9 

[1]CurrentPatentAssignee:AGIOSPHARMACEUTICALSINC;SOLIDSTATEPHARMA-WO2019/104134,2019,A1Locationinpatent:Paragraph00173

1260075-17-9   
N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamidehemisulfate 

[1]CurrentPatentAssignee:AGIOSPHARMACEUTICALSINC;SOLIDSTATEPHARMA-WO2019/104134,2019,A1Locationinpatent:Paragraph00203

[1]CurrentPatentAssignee:AGIOSPHARMACEUTICALSINC;SOLIDSTATEPHARMA-WO2019/104134,2019,A1

[1]CurrentPatentAssignee:AGIOSPHARMACEUTICALSINC;SOLIDSTATEPHARMA-WO2019/104134,2019,A1

Literature

Title: Kung C, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 2017;130(11):1347-1356.

Title: Rab MAE, et al. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021;106(1):238-249.

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Tags:1260075-17-9 Molecular Formula|1260075-17-9 MDL|1260075-17-9 SMILES|1260075-17-9 Pkr-in-1