Home Other Building Blocks 1254205-52-1
1254205-52-1,MFCD29049510
Catalog No.:AA009CHD

1254205-52-1 | RQ-00203078

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$16.00   $11.00
- +
5mg
98+%
in stock  
$38.00   $27.00
- +
10mg
98+%
in stock  
$57.00   $40.00
- +
50mg
98+%
in stock  
$151.00   $106.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CHD
Chemical Name:
RQ-00203078
CAS Number:
1254205-52-1
Molecular Formula:
C21H13ClF6N2O5S
Molecular Weight:
554.8467
MDL Number:
MFCD29049510
SMILES:
Clc1cc(cnc1N(S(=O)(=O)c1ccc(cc1)C(=O)O)Cc1ccc(cc1)OC(F)(F)F)C(F)(F)F
Properties
Computed Properties
 
Complexity:
852  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
5.6  

Upstream Synthesis Route

[1]Patent:WO2010/125831,2010,A1,.Locationinpatent:Page/Pagecolumn47

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,#23,p.5364-5368

[2]BioorganicandMedicinalChemistryLetters,2014,vol.24,#23,p.5364-5368

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,#23,p.5364-5368

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,#23,p.5364-5368

Literature

Title: Masashi Ohmi, et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8.

Title: Yoshihiko Okamoto, et al. Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol. 2012 May;40(5):1431-40.

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SDS
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Tags:1254205-52-1 Molecular Formula|1254205-52-1 MDL|1254205-52-1 SMILES|1254205-52-1 RQ-00203078