Home Other Building Blocks 1338247-35-0
1338247-35-0,MFCD17019327
Catalog No.:AA009CJB

1338247-35-0 | BMS-5

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$18.00   $13.00
- +
5mg
98%
in stock  
$44.00   $31.00
- +
50mg
98%
in stock  
$148.00   $103.00
- +
100mg
98%
in stock  
$192.00   $135.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CJB
Chemical Name:
BMS-5
CAS Number:
1338247-35-0
Molecular Formula:
C17H14Cl2F2N4OS
Molecular Weight:
431.2871
MDL Number:
MFCD17019327
SMILES:
O=C(C(C)C)Nc1ncc(s1)c1cc(nn1c1c(Cl)cccc1Cl)C(F)F
Properties
Computed Properties
 
Complexity:
523  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
5.1  

Literature

Title: Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3.

Journal: British journal of pharmacology 20180601

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120411

Title: LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

Journal: The Journal of cell biology 20101004

Title: Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.

Journal: Molecular cancer therapeutics 20081101

Title: Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.

Title: Petrilli A, et al. LIM Domain Kinases as Potential Therapeutic Targets for Neurofibromatosis Type 2.Oncogene. Oncogene. 2014 Jul 3;33(27):3571-82.

Title: Lunardi P, et al. Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction. Mol Neurobiol. 2017 Jan 13.

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SDS
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