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1265229-25-1,MFCD28502053
Catalog No.:AA009CJH

1265229-25-1 | CH5183284

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$36.00   $25.00
- +
10mg
98%
in stock  
$53.00   $37.00
- +
25mg
98%
in stock  
$89.00   $62.00
- +
50mg
98%
in stock  
$140.00   $98.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CJH
Chemical Name:
CH5183284
CAS Number:
1265229-25-1
Molecular Formula:
C20H16N6O
Molecular Weight:
356.3806
MDL Number:
MFCD28502053
SMILES:
Cc1nc2c([nH]1)cc(cc2)n1ncc(c1N)C(=O)c1cc2c([nH]1)cccc2
Properties
Computed Properties
 
Complexity:
573  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Literature

Title: The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor.

Journal: Molecular cancer therapeutics 20141101

Title: Nakanishi Y, et al. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Mol Cancer Ther. 2014 Nov;13(11):2547-58.

Title: Nakanishi Y, et al. Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1. Mol Cancer Ther. 2015 Mar;14(3):704-12.

Title: Nakanishi Y, et al. ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor. Mol Cancer Ther. 2015 Dec;14(12):2831-9.

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SDS
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Tags:1265229-25-1 Molecular Formula|1265229-25-1 MDL|1265229-25-1 SMILES|1265229-25-1 CH5183284