Name: Name:Flll32
Brand: AABLOCKS
SKU: AA009VQ6
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA009VQ6

Chemical Name: Flll32

CAS Number: 1226895-15-3

Molecular Formula: C28H32O6

Molecular Weight: 464.5501

MDL Number: MFCD27976793

SMILES: COc1cc(/C=C/C(=O)C2(CCCCC2)C(=O)/C=C/c2ccc(c(c2)OC)OC)ccc1OC

Properties

Complexity: 668

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 2

Formal Charge: 0

Heavy Atom Count: 34

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 10

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 5.8

Downstream Synthesis Route

628-77-3

160096-59-3

1226895-15-3

[1]Patent:WO2010/121007,2010,A1.Locationinpatent:Page/Pagecolumn5;14-15

Literature fold

Title: Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice.

Journal: Investigational new drugs20120601

Title: Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.

Journal: PloS one20120101

Title: STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH⁺/CD133⁺ stem cell-like human colon cancer cells.

Journal: Biochemical and biophysical research communications20111216

Title: Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog.

Journal: Archives of otolaryngology--head & neck surgery20110501

Title: Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.

Journal: International journal of oncology20110101

Title: The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines.

Journal: BMC cancer20110101

Title: IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells.

Journal: Cell cycle (Georgetown, Tex.)20100901

Title: Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells.

Journal: Cancer research20100315

Title: The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

Journal: Molecular cancer20100101

Title: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

Journal: Molecular cancer20100101

Title: Bill MA, et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol Cancer. 2010 Jun 25;9:165.

Title: Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreaticand breast cancer cells. Cancer Res. 2010 Mar 15;70(6):2445-54.

1226895-15-3 | Flll32