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142439-95-0
Catalog No.:AA00A1E9

142439-95-0 | Sp-Cyclic AMPS (sodium salt)

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1mg
≥98%
in stock  
$98.00   $68.00
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5mg
≥98%
in stock  
$432.00   $302.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00A1E9
Chemical Name:
Sp-Cyclic AMPS (sodium salt)
CAS Number:
142439-95-0
Molecular Formula:
C10H11N5NaO5PS
Molecular Weight:
367.2534
SMILES:
O[C@@H]1[C@@H]2O[P@@](=O)([S-])OC[C@H]2O[C@H]1n1cnc2c1ncnc2N.[Na+]
Properties
Computed Properties
 
Complexity:
508  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  

Literature

Title: Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30(1):16-31.

Title: L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253(5024):1132-5.

Title: Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287(2):1210-9.

Title: P A Connelly,et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32.

Title: G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77.

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SDS
Tags:142439-95-0 Molecular Formula|142439-95-0 MDL|142439-95-0 SMILES|142439-95-0 Sp-Cyclic AMPS (sodium salt)