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153653-30-6,MFCD00925095
Catalog No.:AA00ABH1

153653-30-6 | Dofequidar fumarate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$95.00   $67.00
- +
2mg
95%
1 week  
$110.00   $77.00
- +
5mg
95%
1 week  
$146.00   $102.00
- +
10mg
95%
1 week  
$203.00   $142.00
- +
25mg
95%
1 week  
$352.00   $247.00
- +
50mg
95%
1 week  
$626.00   $438.00
- +
100mg
95%
1 week  
$884.00   $619.00
- +
500mg
95%
1 week  
$1,795.00   $1,256.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABH1
Chemical Name:
Dofequidar fumarate
CAS Number:
153653-30-6
Molecular Formula:
C34H35N3O7
Molecular Weight:
597.6576
MDL Number:
MFCD00925095
SMILES:
OC(CN1CCN(CC1)C(=O)C(c1ccccc1)c1ccccc1)COc1cccc2c1cccn2.OC(=O)/C=C/C(=O)O
Properties
Computed Properties
 
Complexity:
771  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Identification of small molecule sphingomyelin synthase inhibitors.

Journal: European journal of medicinal chemistry 20140212

Title: Nakanishi O, et al. Potentiation of the antitumor activity by a novel quinoline compound, MS-209, in multidrug-resistant solid tumor cell lines. Oncol Res. 1997;9(2):61-9.

Title: Naito M, et al. MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clin Cancer Res. 2002 Feb;8(2):582-8.

Title: Nokihara H, et al. A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells. Jpn J Cancer Res. 2001 Jul;92(7):785-92.

Title: Katayama R, et al. Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci. 2009 Nov;100(11):2060-8.

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SDS
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