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168682-53-9,MFCD27982957
Catalog No.:AA00ABHD

168682-53-9 | Ezatiostat

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$35.00   $25.00
- +
5mg
98%
in stock  
$85.00   $60.00
- +
10mg
98%
in stock  
$143.00   $100.00
- +
50mg
98
in stock  
$688.00   $482.00
- +
100mg
98
in stock  
$1,129.00   $790.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABHD
Chemical Name:
Ezatiostat
CAS Number:
168682-53-9
Molecular Formula:
C27H35N3O6S
Molecular Weight:
529.6483
MDL Number:
MFCD27982957
SMILES:
CCOC(=O)[C@H](CCC(=O)N[C@H](C(=O)N[C@H](c1ccccc1)C(=O)OCC)CSCc1ccccc1)N
Properties
Computed Properties
 
Complexity:
725  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
17  
XLogP3:
2.7  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A phase 2 randomized multicenter study of 2 extended dosing schedules of oral ezatiostat in low to intermediate-1 risk myelodysplastic syndrome.

Journal: Cancer 20120415

Title: Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS).

Journal: Journal of hematology & oncology 20120101

Title: Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome.

Journal: Journal of hematology & oncology 20120101

Title: Failure of hypomethylating agent-based therapy in myelodysplastic syndromes.

Journal: Seminars in oncology 20111001

Title: Oral ezatiostat HCl (Telintra®, TLK199) and idiopathic chronic neutropenia (ICN): a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat, a glutathione S-transferase P1-1 (GSTP1-1) inhibitor.

Journal: Journal of hematology & oncology 20110101

Title: Novel therapies for myelodysplastic syndromes.

Journal: Hematology/oncology clinics of North America 20100401

Title: Oral Ezatiostat HCl (TLK199) and Myelodysplastic syndrome: a case report of sustained hematologic response following an abbreviated exposure.

Journal: Journal of hematology & oncology 20100101

Title: Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome.

Journal: Blood 20090625

Title: Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome.

Journal: Journal of hematology & oncology 20090101

Title: Treatment of MDS: something old, something new, something borrowed..

Journal: Hematology. American Society of Hematology. Education Program 20090101

Title: Developmental therapeutics for myelodysplastic syndromes.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20060101

Title: TLK-199 (Telik).

Journal: IDrugs : the investigational drugs journal 20050801

Title: Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid.

Journal: Gastroenterology 20040801

Title: Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20

Title: Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298(1):339-45.

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