+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
1572414-83-5,MFCD28099817
Catalog No.:AA00ABI1

1572414-83-5 | 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$112.00   $78.00
- +
10mg
98%
in stock  
$164.00   $115.00
- +
25mg
95%
in stock  
$241.00   $169.00
- +
50mg
98%
in stock  
$259.00   $181.00
- +
1000mg
95
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ABI1
Chemical Name:
2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine
CAS Number:
1572414-83-5
Molecular Formula:
C23H24N6
Molecular Weight:
384.4769
MDL Number:
MFCD28099817
SMILES:
Cc1cnc(nc1NCc1ccc(cc1)n1nncc1)c1ccccc1C(C)C
Properties
Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.6  

Literature

Title: Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Journal: Journal of medicinal chemistry 20141009

Title: Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10(4):298-304.

Title: Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 1572414-83-5
Building Blocks
More >
Tags:1572414-83-5 Molecular Formula|1572414-83-5 MDL|1572414-83-5 SMILES|1572414-83-5 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine
Catalog No.: AA00ABI1
1572414-83-5,MFCD28099817
1572414-83-5 | 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine
Pack Size： 5mg
Purity： 98%
in stock
$112.00 $78.00
Pack Size： 10mg
Purity： 98%
in stock
$164.00 $115.00
Pack Size： 25mg
Purity： 95%
in stock
$241.00 $169.00
Pack Size： 50mg
Purity： 98%
in stock
$259.00 $181.00
Pack Size： 1000mg
Purity： 95
in stock
$4,634.00 $3,244.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00ABI1
Chemical Name: 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine
CAS Number: 1572414-83-5
Molecular Formula: C23H24N6
Molecular Weight: 384.4769
MDL Number: MFCD28099817
SMILES: Cc1cnc(nc1NCc1ccc(cc1)n1nncc1)c1ccccc1C(C)C
Properties
Complexity: 492  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 6  
XLogP3: 4.6  
Literature fold

Title: Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Journal: Journal of medicinal chemistry20141009

Title: Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10(4):298-304.

Title: Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.

Related Products of of 1572414-83-5
Building Blocks More >
1629268-19-4
1629268-19-4
K-Ras G12C-IN-3
AA00ABLG | MFCD28386555
16778-74-8
16778-74-8
4H-1,2,4-Triazole,3,4-dimethyl-(8CI,9CI)
AA00ABSW | MFCD11857829
15285-15-1
15285-15-1
3-Chloro-5-methyl-1h-1,2,4-triazole
AA00AC44 | MFCD01451378
17146-08-6
17146-08-6
PHENETHYLDIMETHYLCHLOROSILANE
AA00ACCM | MFCD00053210
189035-43-6
189035-43-6
SIALYLGLYCOPEPTIDE
AA00ACRV | MFCD15072192
19547-38-7
19547-38-7
Methyl picolinimidate
AA00ACXL | MFCD00047437
144889-52-1
144889-52-1
1-Acetoxy-4-(N-acetyl-L-cysteinyl)-2-butanone
AA00AD4S | MFCD27977605
172168-03-5
172168-03-5
4-[(4-Methoxyphenyl)methyl]-4-methyl-2-phenyl-5(4H)-oxazolone
AA00ADBS | MFCD16293862
165331-08-8
165331-08-8
2-Azidoethyl beta-D-Glucopyranoside
AA00ADH0 | MFCD15072142
1630-34-8
1630-34-8
O-Acetyl Pseudoephedrine Hydrochloride
AA00ADQB | MFCD27967316
Submit
© 2017 AA BLOCKS, INC. All rights reserved.