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Home Other Building Blocks 1608125-21-8
1608125-21-8,MFCD28902228
Catalog No.:AA00ABK5

1608125-21-8 | Amg319

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
99%
in stock  
$304.00   $213.00
- +
25mg
99%
in stock  
$570.00   $399.00
- +
100mg
95%
in stock  
$779.00   $545.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABK5
Chemical Name:
Amg319
CAS Number:
1608125-21-8
Molecular Formula:
C21H16FN7
Molecular Weight:
385.3970
MDL Number:
MFCD28902228
SMILES:
Fc1ccc2c(c1)nc(c(c2)[C@@H](Nc1ncnc2c1nc[nH]2)C)c1ccccn1
Properties
Computed Properties
 
Complexity:
551  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Literature

Title: Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Journal: Journal of medicinal chemistry 20150108

Title: Cushing TD, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem. 2015 Jan 8;58(1):480-511.

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