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Home Other Building Blocks 1818885-28-7
1818885-28-7,MFCD29472237
Catalog No.:AA00ABK6

1818885-28-7 | Arv-825

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$132.00   $92.00
- +
5mg
97%
in stock  
$290.00   $203.00
- +
10mg
97%
in stock  
$343.00   $240.00
- +
25mg
97%
in stock  
$522.00   $365.00
- +
50mg
97%
in stock  
$690.00   $483.00
- +
250mg
98%
in stock  
$2,472.00   $1,731.00
- +
1g
98%
in stock  
$5,466.00   $3,826.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABK6
Chemical Name:
Arv-825
CAS Number:
1818885-28-7
Molecular Formula:
C46H47ClN8O9S
Molecular Weight:
923.4316
MDL Number:
MFCD29472237
SMILES:
O=C1CCC(C(=O)N1)N1C(=O)c2c(C1=O)c(NCCOCCOCCOCCOc1ccc(cc1)NC(=O)C[C@@H]1N=C(c3ccc(cc3)Cl)c3c(n4c1nnc4C)sc(c3C)C)ccc2
Properties
Computed Properties
 
Complexity:
1720  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
19  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ARVINAS-WO2015/160845,2015,A2

[2]CurrentPatentAssignee:YALEUNIVERSITY-WO2019/148055,2019,A1

[1]CurrentPatentAssignee:ARVINAS-WO2015/160845,2015,A2

[2]CurrentPatentAssignee:YALEUNIVERSITY-WO2019/148055,2019,A1

[1]CurrentPatentAssignee:ARVINAS-WO2015/160845,2015,A2

[2]CurrentPatentAssignee:YALEUNIVERSITY-WO2019/148055,2019,A1

[1]CurrentPatentAssignee:ARVINAS-WO2015/160845,2015,A2

[1]CurrentPatentAssignee:ARVINAS-WO2015/160845,2015,A2

Literature

Title: Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

Journal: Chemistry & biology 20150618

Title: Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63.

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SDS
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Tags:1818885-28-7 Molecular Formula|1818885-28-7 MDL|1818885-28-7 SMILES|1818885-28-7 Arv-825