Home Other Building Blocks 175026-96-7
175026-96-7,MFCD03265970
Catalog No.:AA00ABLW

175026-96-7 | Nqdi-1

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50mg
98+%
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$6.00   $4.00
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100mg
98+%
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$8.00   $6.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABLW
Chemical Name:
Nqdi-1
CAS Number:
175026-96-7
Molecular Formula:
C19H13NO4
Molecular Weight:
319.3108
MDL Number:
MFCD03265970
SMILES:
CCOC(=O)c1c(=O)[nH]c2c3c1c1ccccc1c(=O)c3ccc2
Properties
Computed Properties
 
Complexity:
623  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.5  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2006,vol.14,#9,p.2880-2886

[2]BollettinoChimicoFarmaceutico,1995,vol.134,#10,p.564-5568

[3]Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.19,p.1964

[4]Patent:US1891317,1931,,

[5]Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.19,p.1964

[1]JournalofMedicinalChemistry,2001,vol.44,#12,p.2004-2014

Literature

Title: Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1).

Journal: Journal of medicinal chemistry 20110428

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Volynets GP, et al. Identification of 3H-naphtho,2,3-dequinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J Med Chem. 2011 Apr 28;54(8):2680-6.

Title: Hao H, et al. NQDI-1, an inhibitor of ASK1 attenuates acute perinatal hypoxic-ischemic cerebral injury by modulating cell death. Mol Med Rep. 2016 Jun;13(6):4585-92.

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SDS
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