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1819363-80-8,MFCD28100807
Catalog No.:AA00ABM3

1819363-80-8 | PFI3

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$29.00   $21.00
- +
5mg
99+%
in stock  
$73.00   $51.00
- +
10mg
99+%
in stock  
$95.00   $67.00
- +
50mg
99+%
in stock  
$161.00   $113.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABM3
Chemical Name:
PFI3
CAS Number:
1819363-80-8
Molecular Formula:
C19H19N3O2
Molecular Weight:
321.3731
MDL Number:
MFCD28100807
SMILES:
O=C(c1ccccc1O)/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1
Properties
Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Literature

Title: BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior.

Journal: Biological psychiatry 20161101

Title: Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.

Journal: Journal of medicinal chemistry 20160526

Title: Vangamudi B, et al. The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. Cancer Res. 2015 Sep 15;75(18):3865-78.

Title: Fedorov O, et al. Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. Sci Adv. 2015 Nov 13;1(10):e1500723.

Title: Gerstenberger BS, et al. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. J Med Chem. 2016 May 26;59(10):4800-11.

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