Home Other Building Blocks 166095-21-2
166095-21-2,MFCD25977742
Catalog No.:AA00ABOD

166095-21-2 | Bms-191095

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
100%
1 week  
$170.00   $119.00
- +
5mg
100%
1 week  
$358.00   $251.00
- +
10mg
100%
1 week  
$483.00   $338.00
- +
25mg
100%
1 week  
$776.00   $544.00
- +
50mg
100%
1 week  
$1,082.00   $757.00
- +
100mg
100%
1 week  
$1,452.00   $1,016.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABOD
Chemical Name:
Bms-191095
CAS Number:
166095-21-2
Molecular Formula:
C22H21ClN4O2
Molecular Weight:
408.8807
MDL Number:
MFCD25977742
SMILES:
N#Cc1ccc2c(c1)[C@H](N(c1ccc(cc1)Cl)Cc1ncc[nH]1)[C@H](C(O2)(C)C)O
Properties
Computed Properties
 
Complexity:
615  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Literature

Title: The cytoprotective action of the potassium channel opener BMS-191095 in C2C12 myoblasts is related to the modulation of calcium homeostasis.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Title: ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080601

Title: GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion.

Journal: Basic research in cardiology 20070701

Title: Chronic preconditioning: a novel approach for cardiac protection.

Journal: American journal of physiology. Heart and circulatory physiology 20070501

Title: The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070201

Title: Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.

Journal: American journal of physiology. Heart and circulatory physiology 20060601

Title: Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria.

Journal: Brain research bulletin 20050730

Title: Mitochondrial KATP channels in hindlimb remote ischemic preconditioning of skeletal muscle against infarction.

Journal: American journal of physiology. Heart and circulatory physiology 20050201

Title: BMS-191095, a cardioselective mitochondrial K(ATP) opener, inhibits human platelet aggregation by opening mitochondrial K(ATP) channels.

Journal: Archives of pharmacal research 20050101

Title: Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.

Journal: Journal of medicinal chemistry 20040226

Title: The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioning.

Journal: Neuroreport 20040209

Title: In vivo characterization of the mitochondrial selective K(ATP) opener (3R)-trans-4-((4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1-benzopyran-6-carbonitril monohydrochloride (BMS-191095): cardioprotective, hemodynamic, and electrophysiological effects.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.

Journal: Cardiovascular research 20020815

Title: Pharmacologic profile of the selective mitochondrial-K(ATP) opener BMS-191095 for treatment of acute myocardial ischemia.

Journal: Cardiovascular drug reviews 20020101

Title: Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

Journal: Journal of medicinal chemistry 20010524

Title: Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 166095-21-2
Tags:166095-21-2 Molecular Formula|166095-21-2 MDL|166095-21-2 SMILES|166095-21-2 Bms-191095