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1642300-78-4,MFCD30489756
Catalog No.:AA00ABPU

1642300-78-4 | KPT-8602 (Z-isomer)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
96%
1 week  
$317.00   $222.00
- +
5mg
96%
1 week  
$603.00   $422.00
- +
10mg
96%
1 week  
$793.00   $555.00
- +
50mg
96%
1 week  
$2,241.00   $1,569.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ABPU
Chemical Name:
KPT-8602 (Z-isomer)
CAS Number:
1642300-78-4
Molecular Formula:
C17H10F6N6O
Molecular Weight:
428.2913
MDL Number:
MFCD30489756
SMILES:
NC(=O)/C(=C\n1cnc(n1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/c1cncnc1
Properties
Computed Properties
 
Complexity:
626  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.5  

Literature

Title: Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25.

Title: Hing ZA et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Jun 21.

Title: Etchin J et al. KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2016 Jun 24.

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SDS
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Tags:1642300-78-4 Molecular Formula|1642300-78-4 MDL|1642300-78-4 SMILES|1642300-78-4 KPT-8602 (Z-isomer)
Catalog No.: AA00ABPU
1642300-78-4,MFCD30489756
1642300-78-4 | KPT-8602 (Z-isomer)
Pack Size： 1mg
Purity： 96%
1 week
$317.00 $222.00
Pack Size： 5mg
Purity： 96%
1 week
$603.00 $422.00
Pack Size： 10mg
Purity： 96%
1 week
$793.00 $555.00
Pack Size： 50mg
Purity： 96%
1 week
$2,241.00 $1,569.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00ABPU
Chemical Name: KPT-8602 (Z-isomer)
CAS Number: 1642300-78-4
Molecular Formula: C17H10F6N6O
Molecular Weight: 428.2913
MDL Number: MFCD30489756
SMILES: NC(=O)/C(=C\n1cnc(n1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/c1cncnc1
Properties
Complexity: 626  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.5  
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