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143692-48-2,MFCD01941362
Catalog No.:AA00AKO0

143692-48-2 | GYKI53655 HCl

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1mg
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5mg
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$200.00   $140.00
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10mg
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AKO0
Chemical Name:
GYKI53655 HCl
CAS Number:
143692-48-2
Molecular Formula:
C19H21ClN4O3
Molecular Weight:
388.8480
MDL Number:
MFCD01941362
SMILES:
CNC(=O)N1N=C(c2ccc(cc2)N)c2c(CC1C)cc1c(c2)OCO1.Cl
Properties
Computed Properties
 
Complexity:
561  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity.

Journal: Neuron 20120322

Title: Nonlinear interactions between excitatory and inhibitory retinal synapses control visual output.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111019

Title: Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527

Title: Antagonism of recombinant and native GluK3-containing kainate receptors.

Journal: Neuropharmacology 20090101

Title: TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.

Journal: Science (New York, N.Y.) 20071102

Title: Fast regulation of axonal growth cone motility by electrical activity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070718

Title: Anxiolytic-like effects through a GLUK5 kainate receptor mechanism.

Journal: Neuropharmacology 20070601

Title: Pharmacological characterization of cGMP regulation by the biarylpropylsulfonamide class of positive, allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20061001

Title: Both Ca2+-permeable and -impermeable AMPA receptors contribute to primary synaptic drive onto rat dorsal horn neurons.

Journal: The Journal of physiology 20060815

Title: Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists.

Journal: Behavioural pharmacology 20060601

Title: Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn.

Journal: Neuroscience 20060512

Title: Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators.

Journal: Brain research 20060303

Title: Molecular mechanism of AMPA receptor noncompetitive antagonism.

Journal: Neuron 20051020

Title: Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs.

Journal: Nature neuroscience 20051001

Title: Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

Journal: Journal of neurophysiology 20050901

Title: Simultaneous contribution of two rod pathways to AII amacrine and cone bipolar cell light responses.

Journal: Journal of neurophysiology 20050301

Title: Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

Title: Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices.

Journal: Neuropharmacology 20040901

Title: Distinct properties of carbachol- and DHPG-induced network oscillations in hippocampal slices.

Journal: Neuropharmacology 20040901

Title: Functional properties of spontaneous EPSCs and non-NMDA receptors in rod amacrine (AII) cells in the rat retina.

Journal: The Journal of physiology 20030615

Title: Involvement of post-synaptic kainate receptors during synaptic transmission between unitary connections in rat neocortex.

Journal: The European journal of neuroscience 20030601

Title: [Kainate receptors. Their function in the regulation of GABAergic synaptic transmission in the hippocampus].

Journal: Revista de neurologia 20030501

Title: The selective iGluR1-4 (AMPA) antagonist LY300168 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioural signs of morphine withdrawal.

Journal: Neuropharmacology 20030101

Title: The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.

Journal: British journal of pharmacology 20021201

Title: AMPA receptors and kainate receptors encode different features of afferent activity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020901

Title: Functional characteristics of non-NMDA-type ionotropic glutamate receptor channels in AII amacrine cells in rat retina.

Journal: The Journal of physiology 20020701

Title: Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes.

Journal: Neurobiology of disease 20020301

Title: AMPA-induced Ca(2+) influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry.

Journal: European journal of pharmacology 20020301

Title: Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones.

Journal: Brain research 20020201

Title: Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA-, alpha(1)- and 5-HT(2A)-receptors.

Journal: British journal of pharmacology 20020101

Title: AMPA receptor properties at the synapse between retinal afferents and thalamocortical cells in the dorsal lateral geniculate nucleus of the rat.

Journal: Neuroscience letters 20011201

Title: A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP.

Journal: Neuron 20011120

Title: Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.

Journal: Brain research bulletin 20010601

Title: Blockade of AMPA/kainate receptors can either decrease or increase the survival of cultured neocortical cells depending on the stage of maturation.

Journal: Neurochemistry international 20010501

Title: Contributions of AMPA- and kainate-sensitive receptors to the photopic electroretinogram of the Xenopus retina.

Journal: Visual neuroscience 20010101

Title: (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices.

Journal: European journal of pharmacology 20000804

Title: Oxytocin modulates glutamatergic synaptic transmission between cultured neonatal spinal cord dorsal horn neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19980401

Title: Bleakman D, et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology. 1996;35(12):1689-702.

Title: Chizh BA, et al. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord. Br J Pharmacol. 1994 Jul;112(3):843-6.

Title: Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55(3):387-91.

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Tags:143692-48-2 Molecular Formula|143692-48-2 MDL|143692-48-2 SMILES|143692-48-2 GYKI53655 HCl