[1]Jackson,PaulF.;Cole,DerekC.;Slusher,BarbaraS.;Stetz,SusanL.;Ross,LaurieE.;etal.[JournalofMedicinalChemistry,1996,vol.39,#2,p.619-622]
[1]CurrentPatentAssignee:UNIVERSITYOFMICHIGAN-WO2008/8483,2008,A2Locationinpatent:Page/Pagecolumn103
[1]Jackson,PaulF.;Cole,DerekC.;Slusher,BarbaraS.;Stetz,SusanL.;Ross,LaurieE.;etal.[JournalofMedicinalChemistry,1996,vol.39,#2,p.619-622]
[1]CurrentPatentAssignee:EISAICOLTD-US6384022,2002,B1
[2]CurrentPatentAssignee:EISAICOLTD-US5977090,1999,A
[3]CurrentPatentAssignee:EISAICOLTD-US6017903,2000,A
Title: NAAG peptidase inhibitors block cognitive deficit induced by MK-801 and motor activation induced by d-amphetamine in animal models of schizophrenia.
Journal: Translational psychiatry 20120701
Title: Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.
Journal: The Journal of biological chemistry 20120622
Title: Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
Journal: Amino acids 20120601
Title: mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia.
Journal: Schizophrenia research 20120401
Title: Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.
Journal: Psychopharmacology 20110701
Title: Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies.
Journal: Journal of translational medicine 20110101
Title: Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101
Title: Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid.
Journal: The Prostate 20100215
Title: Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.
Journal: European journal of pharmacology 20100210
Title: N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.
Journal: Neuropharmacology 20100101
Title: Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.
Journal: Journal of neurochemistry 20100101
Title: GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.
Journal: Journal of neurovirology 20090901
Title: Multivalent scaffolds for affinity maturation of small molecule cell surface binders and their application to prostate tumor targeting.
Journal: Journal of medicinal chemistry 20090122
Title: Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks.
Journal: European journal of pharmacology 20080128
Title: Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.
Journal: Molecular pain 20080101
Title: Progress in the discovery and development of glutamate carboxypeptidase II inhibitors.
Journal: Drug discovery today 20070901
Title: Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
Journal: Journal of medicinal chemistry 20070712
Title: Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.
Journal: Acta crystallographica. Section D, Biological crystallography 20070401
Title: Design, synthesis and pharmacological activity of novel enantiomerically pure phosphonic acid-based NAALADase inhibitors.
Journal: Organic & biomolecular chemistry 20070307
Title: Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.
Journal: Journal of neurochemistry 20070101
Title: Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats.
Journal: The European journal of neuroscience 20070101
Title: Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.
Journal: Neuropharmacology 20061201
Title: Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity.
Journal: Neuroscience 20060811
Title: Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro.
Journal: The Prostate 20060601
Title: Complex character analysis of heart rate variability following brain asphyxia.
Journal: Medical engineering & physics 20060501
Title: 2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice.
Journal: European journal of pharmacology 20060215
Title: Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.
Journal: Advances in experimental medicine and biology 20060101
Title: 2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice.
Journal: Psychopharmacology 20051201
Title: Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.
Journal: Journal of neurochemistry 20050701
Title: Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors.
Journal: Journal of neurochemistry 20050501
Title: Enantiospecificity of glutamate carboxypeptidase II inhibition.
Journal: Journal of medicinal chemistry 20050407
Title: Inhibition of glutamate carboxypeptidase II (NAALADase) protects against dynorphin A-induced ischemic spinal cord injury in rats.
Journal: European journal of pharmacology 20050131
Title: 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia.
Journal: Journal of molecular neuroscience : MN 20050101
Title: N-Acetylated alpha-linked acidic dipeptidase expressed in rat adipocytes is localized in the insulin-responsive glucose transporter (GLUT4) intracellular compartments and involved in the insulin-stimulated GLUT4 recruitment.
Journal: Archives of biochemistry and biophysics 20040401
Title: Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.
Journal: Journal of neurochemistry 20040401
Title: Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.
Journal: Journal of medicinal chemistry 20040325
Title: Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.
Journal: Neuropeptides 20031001
Title: Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.
Journal: Bioorganic & medicinal chemistry letters 20030707
Title: NAALADase inhibition protects motor neurons against chronic glutamate toxicity.
Journal: European journal of pharmacology 20030627
Title: Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Journal: Journal of medicinal chemistry 20030508
Title: Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301
Title: Glutamate carboxypeptidase II inhibition as a novel therapeutic target.
Journal: Advances in experimental medicine and biology 20030101
Title: Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay.
Journal: Analytical biochemistry 20021101
Title: Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.
Journal: Journal of neurochemistry 20021001
Title: Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.
Journal: Journal of medicinal chemistry 20020912
Title: NAALADase (GCP II) inhibition prevents cocaine-kindled seizures.
Journal: Neuropharmacology 20020901
Title: Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.
Journal: European journal of pharmacology 20020222
Title: Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain.
Journal: The Journal of pharmacology and experimental therapeutics 20020201
Title: 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase).
Journal: Molecular imaging 20020101
Title: Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta.
Journal: European journal of pharmacology 20011026
Title: Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes.
Journal: European journal of pharmacology 20010914
Title: Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.
Journal: European journal of pharmacology 20010824
Title: Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.
Journal: Brain research 20010803
Title: Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).
Journal: Synapse (New York, N.Y.) 20010701
Title: Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase).
Journal: Journal of medicinal chemistry 20010201
Title: Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test.
Journal: Neuroscience 20010101
Title: N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.
Journal: Neuroscience 20010101
Title: Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling.
Journal: Neuroscience 20010101
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Title: Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.
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