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Home Other Building Blocks 1577222-14-0
1577222-14-0,MFCD28502263
Catalog No.:AA00AME5

1577222-14-0 | 2-(2,5-Dioxopyrrolidin-1-yl)ethyl methyl fumarate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$116.00   $81.00
- +
50mg
95%
in stock  
$117.00   $82.00
- +
1g
98%
in stock  
$1,132.00   $793.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AME5
Chemical Name:
2-(2,5-Dioxopyrrolidin-1-yl)ethyl methyl fumarate
CAS Number:
1577222-14-0
Molecular Formula:
C11H13NO6
Molecular Weight:
255.2240
MDL Number:
MFCD28502263
SMILES:
COC(=O)/C=C/C(=O)OCCN1C(=O)CCC1=O
Properties
Computed Properties
 
Complexity:
384  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
7  
XLogP3:
-0.9  

Downstream Synthesis Route

[1]Patent:WO2017/108960,2017,A1.Locationinpatent:Page/Pagecolumn59;60

[2]Patent:US2016/228376,2016,A1.Locationinpatent:Paragraph0182;0189-0191

(E)-but-2-enedioicacid2-(2,5-dioxo-pyrrolidin-1-yl)ethylester 
  79-22-1    1577222-14-0 

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2017/108960,2017,A1Locationinpatent:Page/Pagecolumn51;52;53;54;55;57;58;59

[1]Patent:WO2017/108960,2017,A1

[2]Patent:WO2017/108960,2017,A1

[3]Patent:WO2017/108960,2017,A1

[4]Patent:WO2017/108960,2017,A1

[5]Patent:WO2017/108960,2017,A1

[6]Patent:WO2017/108960,2017,A1

(2Z)-4-2-(2,5-dioxopyrrolidin-1-yl)ethoxy-4-oxobut-2-enoicacid 
  1577222-14-0 

[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2017/108960,2017,A1

[2]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2017/108960,2017,A1

Literature

Title: Angela Wehr, et al. Relative Bioavailability of Monomethyl Fumarate after Administration of ALKS 8700 in Healthy Subjects (P1.403). Neurology. Apr 2018.

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SDS
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Tags:1577222-14-0 Molecular Formula|1577222-14-0 MDL|1577222-14-0 SMILES|1577222-14-0 2-(2,5-Dioxopyrrolidin-1-yl)ethyl methyl fumarate