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148547-33-5,MFCD00918566
Catalog No.:AA00ANDZ

148547-33-5 | GR 125743

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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00ANDZ
Chemical Name:
GR 125743
CAS Number:
148547-33-5
Molecular Formula:
C25H28N4O2
Molecular Weight:
416.5154
MDL Number:
MFCD00918566
SMILES:
COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(c(c1)C)c1ccncc1
Properties
Computed Properties
 
Complexity:
574  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.6  

Literature

Title: Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists.

Journal: Psychopharmacology 20120301

Title: The effect of maternal ketanserin treatment on foetal 5-HT receptor function in umbilical cord artery of pre-eclamptic patients.

Journal: Neonatology 20070101

Title: In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist.

Journal: European journal of pharmacology 20040919

Title: Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201

Title: Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743.

Journal: Brain research 20011005

Title: Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor.

Journal: British journal of pharmacology 20010701

Title: Site-directed mutagenesis of the 5-HT1B receptor increases the affinity of 5-HT for the agonist low-affinity conformation and reduces the intrinsic activity of 5-HT.

Journal: European journal of pharmacology 20010608

Title: Constitutive activity at serotonin 5-HT(1D) receptors: detection by homologous GTPgammaS versus [(35)S]-GTPgammaS binding isotherms.

Journal: Neuropharmacology 20010101

Title: Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.

Journal: European journal of pharmacology 19990910

Title: Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.

Journal: FEBS letters 19990730

Title: Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970901

Title: Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970601

Title: T Wurch, et al. Induction of a high-affinity ketanserin binding site at the 5-Hydroxytryptamine(1B) receptor by modification of its carboxy-terminal intracellular portion. Characterization of human serotonin 1D and 1B receptors using H-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. Biochem Pharmacol. 2000 May 1;59(9):1117-21.

Title: Roberts, C., et al. The role of 5-HT1B/1D receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European Journal of Pharmacology. 1997 May 12;326(1):23-30.

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