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149092-50-2,MFCD01074971
Catalog No.:AA00AOXS

149092-50-2 | AG 825

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1mg
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$40.00   $28.00
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5mg
≥98%
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$129.00   $90.00
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10mg
≥98%
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$218.00   $152.00
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25mg
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$493.00   $345.00
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50mg
≥96%
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$941.00   $659.00
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100mg
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$1,472.00   $1,030.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AOXS
Chemical Name:
AG 825
CAS Number:
149092-50-2
Molecular Formula:
C19H15N3O3S2
Molecular Weight:
397.4707
MDL Number:
MFCD01074971
SMILES:
N#CC(=Cc1cc(CSc2nc3c(s2)cccc3)c(c(c1)OC)O)C(=O)N
Properties
Computed Properties
 
Complexity:
621  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3.6  

Literature

Title: Developmental defects in zebrafish for classification of EGF pathway inhibitors.

Journal: Toxicology and applied pharmacology 20140115

Title: ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20110701

Title: The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells.

Journal: American journal of physiology. Endocrinology and metabolism 20110501

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K.

Journal: World journal of gastroenterology 20100828

Title: EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor.

Journal: Journal of cellular physiology 20100401

Title: Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells.

Journal: Chembiochem : a European journal of chemical biology 20100301

Title: Degradation of HER2 receptor through hypericin-mediated photodynamic therapy.

Journal: Photochemistry and photobiology 20100101

Title: Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.

Journal: Cancer letters 20091118

Title: ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601

Title: Expression profiles of protein tyrosine kinase genes in human embryonic stem cells.

Journal: Reproduction (Cambridge, England) 20081001

Title: Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.

Journal: Blood 20071201

Title: Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20071001

Title: HER-2/neu raises SHP-2, stops IFN-gamma anti-proliferation in bladder cancer.

Journal: Biochemical and biophysical research communications 20070427

Title: The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway.

Journal: Endocrinology 20070301

Title: Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence.

Journal: Experimental cell research 20070115

Title: Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.

Journal: The American journal of pathology 20061001

Title: Neuregulin-1 isoform induces mitogenesis, KCa and Ca2+ currents in PC12 cells. A comparison with sciatic nerve conditioned medium.

Journal: Brain research 20060919

Title: Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure.

Journal: Endocrinology 20060201

Title: ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801

Title: EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.

Journal: American journal of physiology. Heart and circulatory physiology 20050701

Title: The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery.

Journal: Autonomic & autacoid pharmacology 20050401

Title: Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.

Journal: Molecular biology of the cell 20040901

Title: Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.

Journal: Journal of medicinal chemistry 20031023

Title: Tyrphostins and retinoids cooperate during inhibition of in vitro growth of ovarian cancer cells.

Journal: Cancer letters 20030128

Title: Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2.

Journal: Cancer research 20011015

Title: Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis.

Journal: The Annals of thoracic surgery 20010801

Title: Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.

Journal: Cancer research 20010415

Title: The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.

Journal: Oncogene 20010315

Title: Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins.

Journal: Endocrinology 19970401

Title: Wolfson E, et al. Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer. Cell Death Dis. 2018 Jan 19;9(2):47.

Title: Gazit A, et al. Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J Med Chem. 1993 Nov 12;36(23):3556-64.

Title: He H, et al. Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation. Cancer J. 2001 May-Jun;7(3):191-202.

Title: Rahman A, et al. Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. Elife. 2019 Oct 15;8. pii: e50990.

Title: Ling J, et al. Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis. Medicine (Baltimore). 2018 Jun;97(22):e10775.

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