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150113-99-8,MFCD00798792
Catalog No.:AA00AP0G

150113-99-8 | DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE

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Purity
Availability
Price(USD)
Quantity
  
1mg
>95.00%
3 weeks  
$634.00   $444.00
- +
5mg
>95.00%
3 weeks  
$1,906.00   $1,334.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AP0G
Chemical Name:
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
CAS Number:
150113-99-8
Molecular Formula:
C34H66ClN11O5
Molecular Weight:
744.4115
MDL Number:
MFCD00798792
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)CCl)CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CCCCCCCCC)CCCNC(=N)N
Properties
Computed Properties
 
Complexity:
1100  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
51  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
30  
XLogP3:
2  

Literature

Title: Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis.

Journal: The Journal of biological chemistry 20150320

Title: Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness.

Journal: Oncology reports 20141001

Title: Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20130101

Title: Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme 4 is required for chondrogenic differentiation in ATDC5 cells.

Journal: The FEBS journal 20121101

Title: Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.

Journal: PloS one 20120101

Title: Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization.

Journal: Journal of cellular physiology 20111101

Title: Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.

Journal: Neoplasia (New York, N.Y.) 20100701

Title: Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells.

Journal: Journal of virology 20090901

Title: Secreted cysteine-rich FGF receptor derives from posttranslational processing by furin-like prohormone convertases.

Journal: Biochemical and biophysical research communications 20090501

Title: Mechanism and significance of specific proteolytic cleavage of Reelin.

Journal: Biochemical and biophysical research communications 20090227

Title: Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland.

Journal: Developmental biology 20090115

Title: Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.

Journal: Cells, tissues, organs 20081201

Title: Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin.

Journal: Blood cells, molecules & diseases 20080101

Title: Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide.

Journal: The Journal of biological chemistry 20070601

Title: Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity.

Journal: Infection and immunity 20070101

Title: Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase.

Journal: Biochimica et biophysica acta 20070101

Title: Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos.

Journal: Development genes and evolution 20061001

Title: P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

Journal: The Journal of biological chemistry 20050513

Title: Biosynthesis and secretion of insect lipoprotein: involvement of furin in cleavage of the apoB homolog, apolipophorin-II/I.

Journal: Journal of lipid research 20050301

Title: Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation.

Journal: The Journal of biological chemistry 20041203

Title: Activation of MMP-2 in response to vascular injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP.

Journal: American journal of physiology. Heart and circulatory physiology 20041201

Title: BCL-2-induced glioma cell invasiveness depends on furin-like proteases.

Journal: Journal of neurochemistry 20041201

Title: Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model.

Journal: The American journal of pathology 20040601

Title: Latent TGF-beta1 activation by platelets.

Journal: Journal of cellular physiology 20040401

Title: The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.

Journal: Nature structural biology 20030701

Title: Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation.

Journal: Arthritis and rheumatism 20030401

Title: Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells.

Journal: Journal of cellular biochemistry 20030201

Title: Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.

Journal: The American journal of pathology 20030201

Title: Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation.

Journal: The Journal of biological chemistry 20010921

Title: Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010615

Title: Furin cleavage of the respiratory syncytial virus fusion protein is not a requirement for its transport to the surface of virus-infected cells.

Journal: The Journal of general virology 20010601

Title: Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide.

Journal: Journal of neuroscience research 19990101

Title: Processing of proendothelin-1 by human furin convertase.

Journal: FEBS letters 19950410

Title: Inhibition of convertase-related processing of proendothelin-1.

Journal: Journal of cardiovascular pharmacology 19950101

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