161600-01-7,MFCD00931223
Catalog No.:AA00AP11

161600-01-7 | 5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$168.00   $117.00
- +
10mg
in stock  
$304.00   $213.00
- +
25mg
in stock  
$571.00   $400.00
- +
50mg
in stock  
$928.00   $650.00
- +
100mg
in stock  
$1,559.00   $1,092.00
- +
500mg
in stock  
$4,892.00   $3,425.00
- +
1000mg
in stock  
$7,790.00   $5,453.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00AP11
Chemical Name:
5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione
CAS Number:
161600-01-7
Molecular Formula:
C21H16FNO3S
Molecular Weight:
381.4200
MDL Number:
MFCD00931223
SMILES:
O=C1NC(=O)C(S1)Cc1ccc2c(c1)ccc(c2)OCc1ccccc1F
Properties
Computed Properties
 
Complexity:
560  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.9  

Literature

Title: A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4.

Journal: Toxicology and applied pharmacology 20120901

Title: Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression.

Journal: Analytical biochemistry 20110701

Title: MCC-555-induced NAG-1 expression is mediated in part by KLF4.

Journal: European journal of pharmacology 20100710

Title: High-throughput quantification of a novel thiazolidinedione MCC-555 in rat plasma by ultra-fast liquid chromatography and its application in pharmacokinetic studies.

Journal: Talanta 20090430

Title: Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways.

Journal: Molecular cancer therapeutics 20080901

Title: PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

Journal: American journal of physiology. Endocrinology and metabolism 20071201

Title: Investigation of the lipophilic behaviour of some thiazolidinediones. Relationships with PPAR-gamma activity.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

Title: Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.

Journal: International journal of oncology 20070501

Title: Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501

Title: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells.

Journal: Molecular cancer therapeutics 20060501

Title: Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat.

Journal: Bone 20060101

Title: Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation.

Journal: Experimental cell research 20051015

Title: A novel thiazolidinedione MCC-555 down-regulates tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1 in vascular endothelial cells.

Journal: Atherosclerosis 20050901

Title: RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

Title: Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat.

Journal: International journal of experimental pathology 20030401

Title: [KRP-297, MCC-555].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011101

Title: A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties.

Journal: The Journal of biological chemistry 19981204

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Related Products of 161600-01-7
Tags:161600-01-7 Molecular Formula|161600-01-7 MDL|161600-01-7 SMILES|161600-01-7 5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione
Catalog No.: AA00AP11
161600-01-7,MFCD00931223
161600-01-7 | 5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione
Pack Size: 1mg
Purity: ≥98%
in stock
$63.00 $44.00
Pack Size: 5mg
Purity: ≥98%
in stock
$168.00 $117.00
Pack Size: 10mg
Purity:
in stock
$304.00 $213.00
Pack Size: 25mg
Purity:
in stock
$571.00 $400.00
Pack Size: 50mg
Purity:
in stock
$928.00 $650.00
Pack Size: 100mg
Purity:
in stock
$1,559.00 $1,092.00
Pack Size: 500mg
Purity:
in stock
$4,892.00 $3,425.00
Pack Size: 1000mg
Purity:
in stock
$7,790.00 $5,453.00
Quantity
- +
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bulk Quotation Request
Technical Information
Catalog Number: AA00AP11
Chemical Name: 5-((6-((2-Fluorobenzyl)oxy)naphthalen-2-yl)methyl)thiazolidine-2,4-dione
CAS Number: 161600-01-7
Molecular Formula: C21H16FNO3S
Molecular Weight: 381.4200
MDL Number: MFCD00931223
SMILES: O=C1NC(=O)C(S1)Cc1ccc2c(c1)ccc(c2)OCc1ccccc1F
Properties
Complexity: 560  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 1  
XLogP3: 4.9  
Literature fold

Title: A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4.

Journal: Toxicology and applied pharmacology20120901

Title: Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression.

Journal: Analytical biochemistry20110701

Title: MCC-555-induced NAG-1 expression is mediated in part by KLF4.

Journal: European journal of pharmacology20100710

Title: High-throughput quantification of a novel thiazolidinedione MCC-555 in rat plasma by ultra-fast liquid chromatography and its application in pharmacokinetic studies.

Journal: Talanta20090430

Title: Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways.

Journal: Molecular cancer therapeutics20080901

Title: PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

Journal: American journal of physiology. Endocrinology and metabolism20071201

Title: Investigation of the lipophilic behaviour of some thiazolidinediones. Relationships with PPAR-gamma activity.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20071001

Title: Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.

Journal: International journal of oncology20070501

Title: Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20060501

Title: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells.

Journal: Molecular cancer therapeutics20060501

Title: Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat.

Journal: Bone20060101

Title: Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation.

Journal: Experimental cell research20051015

Title: A novel thiazolidinedione MCC-555 down-regulates tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1 in vascular endothelial cells.

Journal: Atherosclerosis20050901

Title: RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040215

Title: Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat.

Journal: International journal of experimental pathology20030401

Title: [KRP-297, MCC-555].

Journal: Nihon rinsho. Japanese journal of clinical medicine20011101

Title: A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties.

Journal: The Journal of biological chemistry19981204

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