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147-61-5,MFCD00023156
Catalog No.:AA00APTT

147-61-5 | 5-(Hydroxymethyl)-6-methylpyrimidine-2,4(1h,3h)-dione

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50mg
97%
in stock  
$107.00   $75.00
- +
250mg
97%
in stock  
$261.00   $183.00
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1g
97%
in stock  
$565.00   $395.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00APTT
Chemical Name:
5-(Hydroxymethyl)-6-methylpyrimidine-2,4(1h,3h)-dione
CAS Number:
147-61-5
Molecular Formula:
C6H8N2O3
Molecular Weight:
156.1393
MDL Number:
MFCD00023156
SMILES:
OCc1c(C)[nH]c(=O)[nH]c1=O
Properties
Computed Properties
 
Complexity:
244  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
-0.9  

Literature

Title: Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors.

Journal: Bioorganic & medicinal chemistry 20120701

Title: Far-UV photochemical bond cleavage of n-amyl nitrite: bypassing a repulsive surface.

Journal: The journal of physical chemistry. A 20120119

Title: Opposite effects of 5-hydroxymethyluracil on mitogenic response of T cells stimulated through T-cell receptor or through T-cell receptor and CD28 co-receptor molecule.

Journal: Bulletin of experimental biology and medicine 20101201

Title: Experimental study of hepatoprotective activity of hydroxymethyluracil.

Journal: Bulletin of experimental biology and medicine 20070501

Title: Correction of morphological shifts in experimental syringomyelia.

Journal: Bulletin of experimental biology and medicine 20070501

Title: DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.

Journal: The Journal of biological chemistry 20050909

Title: Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.

Journal: Toxicology letters 20050315

Title: DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.

Journal: DNA repair 20050102

Title: Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine.

Journal: Free radical research 20041101

Title: Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.

Journal: Radiation research 20040401

Title: [Hydroxymethyluracil in the correction of adverse effects caused by chemotherapy of malignant neoplasms].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101

Title: Surface salt bridges modulate DNA wrapping by the type II DNA-binding protein TF1.

Journal: Biochemistry 20030729

Title: Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.

Journal: Molecular cell 20030601

Title: Repair of deaminated bases in DNA.

Journal: Free radical biology & medicine 20021001

Title: Endogenous DNA lesions can inhibit the binding of the AP-1 (c-Jun) transcription factor.

Journal: Biochemistry 20020625

Title: The role of surface-exposed lysines in wrapping DNA about the bacterial histone-like protein HU.

Journal: Biochemistry 20020618

Title: Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1.

Journal: The Journal of biological chemistry 20011109

Title: High-affinity DNA binding of HU protein from the hyperthermophile Thermotoga maritima.

Journal: Journal of molecular biology 20010817

Title: Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.

Journal: Carcinogenesis 20010101

Title: Binding activity of replication protein A to single-stranded DNA containing oxidized pyrimidine base.

Journal: Nucleic acids research. Supplement (2001) 20010101

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Tags:147-61-5 Molecular Formula|147-61-5 MDL|147-61-5 SMILES|147-61-5 5-(Hydroxymethyl)-6-methylpyrimidine-2,4(1h,3h)-dione