Home Other Building Blocks 194918-76-8
194918-76-8,MFCD06795869
Catalog No.:AA00AQ7C

194918-76-8 | ACPT-I

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$186.00   $130.00
- +
10mg
≥98%
in stock  
$336.00   $235.00
- +
25mg
≥98%
in stock  
$762.00   $533.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AQ7C
Chemical Name:
ACPT-I
CAS Number:
194918-76-8
Molecular Formula:
C8H11NO6
Molecular Weight:
217.1760
MDL Number:
MFCD06795869
SMILES:
OC(=O)[C@@H]1CC(C[C@@H]1C(=O)O)(N)C(=O)O
Properties
Computed Properties
 
Complexity:
303  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
-4  

Literature

Title: Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity.

Journal: Neurobiology of disease 20120401

Title: Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease.

Journal: British journal of pharmacology 20100901

Title: A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Journal: Journal of medicinal chemistry 20100408

Title: Group III mGlu receptor agonist, ACPT-I, attenuates morphine-withdrawal symptoms after peripheral administration in mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20091113

Title: The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems.

Journal: Neuropharmacology 20090901

Title: Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents.

Journal: Neuropharmacology 20080901

Title: Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070620

Title: The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats.

Journal: Neuroscience 20070316

Title: Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats.

Journal: Amino acids 20070201

Title: Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.

Journal: Bioorganic & medicinal chemistry letters 20060915

Title: Anxiolytic-like effects of group III mGlu receptor ligands in the hippocampus involve GABAA signaling.

Journal: Pharmacological reports : PR 20060101

Title: Anxiolytic action of group II and III metabotropic glutamate receptors agonists involves neuropeptide Y in the amygdala.

Journal: Pharmacological reports : PR 20050101

Title: Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats.

Journal: Neuropharmacology 20040201

Title: Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.

Journal: Journal of medicinal chemistry 20020718

Title: Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.

Journal: Polish journal of pharmacology 20020101

Title: Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor.

Journal: European journal of pharmacology 20000407

Title: Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.

Journal: Journal of medicinal chemistry 19970912

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:194918-76-8 Molecular Formula|194918-76-8 MDL|194918-76-8 SMILES|194918-76-8 ACPT-I