Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Journal: Toxicology 20120904
Title: Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells.
Journal: Oncology reports 20120701
Title: Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells.
Journal: Investigational new drugs 20120601
Title: DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines.
Journal: PloS one 20120101
Title: Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
Journal: PloS one 20120101
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111101
Title: Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines.
Journal: Bioorganic & medicinal chemistry 20110701
Title: A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Journal: Journal of cell science 20110601
Title: Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
Journal: Journal of medicinal chemistry 20110414
Title: Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.
Journal: Nature chemical biology 20110413
Title: Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
Journal: PloS one 20110101
Title: DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.
Journal: Journal of medicinal chemistry 20101223
Title: DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Journal: Experimental oncology 20101201
Title: DNA-PK promotes the survival of young neurons in the embryonic mouse retina.
Journal: Cell death and differentiation 20101101
Title: Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.
Journal: Cancer research 20101101
Title: Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.
Journal: Aging 20101001
Title: Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer.
Journal: Science translational medicine 20100908
Title: DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Journal: Free radical biology & medicine 20100515
Title: Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt.
Journal: Cellular signalling 20100101
Title: ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.
Journal: Journal of radiation research 20100101
Title: Impaired NHEJ function in multiple myeloma.
Journal: Mutation research 20090115
Title: Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro.
Journal: The Journal of biological chemistry 20080418
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase.
Journal: The Journal of pharmacology and experimental therapeutics 20070601
Title: Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060501
Title: DNA end joining activity is reduced in Alzheimer's disease.
Journal: Neurobiology of aging 20060401
Title: Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.
Journal: Nucleic acids research 20060101
Title: Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
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Title: Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.
Journal: British journal of cancer 20051031
Title: Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.
Journal: Blood 20050615
Title: Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
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Title: Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
Journal: Bioorganic & medicinal chemistry letters 20041220
Title: Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.
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Title: A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
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Title: 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
Journal: Bioorganic & medicinal chemistry letters 20030915
Title: Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.
Journal: Cancer research 20030915
Title: LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
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Title: Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 19970701
Title: Differential implications of the oncogene-tumor suppressor gene complex in the geneses of 19 human neoplasias. Evidence in support of the steroid carcinogenesis hypothesis.
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