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14676-52-9,MFCD06208460
Catalog No.:AA00ARY0

14676-52-9 | 2-([1,1'-Biphenyl]-2-yl)acetic acid

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100mg
98%
in stock  
$29.00   $21.00
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250mg
98%
in stock  
$43.00   $30.00
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5g
97%
in stock  
$834.00   $584.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ARY0
Chemical Name:
2-([1,1'-Biphenyl]-2-yl)acetic acid
CAS Number:
14676-52-9
Molecular Formula:
C14H12O2
Molecular Weight:
212.2439
MDL Number:
MFCD06208460
SMILES:
OC(=O)Cc1ccccc1c1ccccc1
NSC Number:
97781
Properties
Properties
 
BP:
402.2°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
231  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.2  

Downstream Synthesis Route

[1]JustusLiebigsAnnalenderChemie,1929,vol.468,p.275

[1]JournaloftheChemicalSociety,1939,p.1838,1840

[1]Tetrahedron,1990,vol.46,p.7539-7555

[1]JustusLiebigsAnnalenderChemie,1971,vol.752,p.115-135

[1]JustusLiebigsAnnalenderChemie,1971,vol.752,p.115-135

[2]OrganicandBiomolecularChemistry,2009,vol.7,p.167-177

[3]ChemistryLetters,2015,vol.44,p.621-623

Literature

Title: A novel protocol for the oral administration of test chemicals to adult zebrafish.

Journal: Zebrafish 20111201

Title: Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative.

Journal: International journal of pharmaceutics 20111031

Title: Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues.

Journal: International journal of toxicology 20110501

Title: Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20110428

Title: Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401

Title: Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina.

Journal: Visual neuroscience 20100701

Title: Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID.

Journal: European journal of medicinal chemistry 20100601

Title: The suitability of tris(hydroxylmethyl) aminomethane (THAM) as a buffering system for hydroxypropyl methylcellulose (HPMC) hydrophilic matrices containing a weak acid drug.

Journal: International journal of pharmaceutics 20100315

Title: Polymers for colon targeted drug delivery.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Towards the design of cyclooxygenase (COX) inhibitors based on 4',5 di-substituted biphenyl acetic acid molecules: a QSAR study with a new DFT based descriptor - nucleus independent chemical shift.

Journal: Journal of molecular modeling 20091001

Title: Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat.

Journal: Journal of pharmaceutical and biomedical analysis 20090815

Title: Mechanisms of drug release in citrate buffered HPMC matrices.

Journal: International journal of pharmaceutics 20090331

Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Percutaneous penetration of felbinac after application of transdermal patches: relationship with pharmacological effects in rats.

Journal: The Journal of pharmacy and pharmacology 20080101

Title: Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.

Journal: BMC musculoskeletal disorders 20080101

Title: Synthesis and pharmacological evaluation of some dual-acting amino-alcohol ester derivatives of flurbiprofen and 2-[1,1'-biphenyl-4-yl]acetic acid: a potential approach to reduce local gastrointestinal toxicity.

Journal: Chemistry & biodiversity 20061101

Title: Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats.

Journal: European journal of pharmacology 20060814

Title: Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20031201

Title: Synthesis, characterization and in vitro evaluation of dimethyl-beta-cyclodextrin-4-biphenylylacetic acid conjugate.

Journal: Journal of drug targeting 20030501

Title: Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system.

Journal: The Journal of toxicological sciences 20030201

Title: Characterization of the interaction between a novel convulsant agent, norbiphen, and GABA(A) and other ligand-gated ion channels.

Journal: Neuropharmacology 20020901

Title: A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats.

Journal: The Journal of antimicrobial chemotherapy 20011201

Title: Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide.

Journal: Chemical communications (Cambridge, England) 20011121

Title: Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

Journal: Pharmacological research 20010901

Title: Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.

Journal: General pharmacology 19971101

Title: Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19960201

Title: Quantitation of GABAA receptor inhibition required for quinolone-induced convulsions in mice.

Journal: The Journal of antimicrobial chemotherapy 19941101

Title: Biphenylacetate, but not theophylline, lethally interacts with ciprofloxacin in mice.

Journal: Pharmacology & toxicology 19931101

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Tags:14676-52-9 Molecular Formula|14676-52-9 MDL|14676-52-9 SMILES|14676-52-9 2-([1,1'-Biphenyl]-2-yl)acetic acid