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Home Amines 1621175-65-2
1621175-65-2,MFCD30182283
Catalog No.:AA00ASBM

1621175-65-2 | N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

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Quantity
  
1mg
98+%
in stock  
$41.00   $29.00
- +
5mg
98+%
in stock  
$101.00   $71.00
- +
10mg
98+%
in stock  
$151.00   $106.00
- +
25mg
98+%
in stock  
$255.00   $178.00
- +
50mg
98+%
in stock  
$432.00   $302.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ASBM
Chemical Name:
N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
CAS Number:
1621175-65-2
Molecular Formula:
C18H19ClN6O2S
Molecular Weight:
418.9005
MDL Number:
MFCD30182283
SMILES:
CNc1nc(NCc2ccc(cc2Cl)NS(=O)(=O)C)cc(n1)c1ccccn1
Properties
Computed Properties
 
Complexity:
589  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Peukert,Stefan;Hughes,Richard;Nunez,Jill;He,Guo;Yan,Zhao;Jain,Rishi;Llamas,Luis;Luchansky,Sarah;Carlson,Adam;Liang,Guiqing;Kunjathoor,Vidya;Pietropaolo,Mike;Shapiro,Jeffrey;Castellana,Anja;Wu,Xiaoping;Bose,Avirup[ACSMedicinalChemistryLetters,2014,vol.5,#10,p.1114-1118]

[1]Peukert,Stefan;Hughes,Richard;Nunez,Jill;He,Guo;Yan,Zhao;Jain,Rishi;Llamas,Luis;Luchansky,Sarah;Carlson,Adam;Liang,Guiqing;Kunjathoor,Vidya;Pietropaolo,Mike;Shapiro,Jeffrey;Castellana,Anja;Wu,Xiaoping;Bose,Avirup[ACSMedicinalChemistryLetters,2014,vol.5,#10,p.1114-1118]

20925-27-3   
N-3-chloro-4-2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinylaminomethylphenylmethanesulfonamide 

[1]ACSMedicinalChemistryLetters,2014,vol.5,p.1114-1118

[2]ACSMedicinalChemistryLetters,2014,vol.5,p.1114-1118

[1]Peukert,Stefan;Hughes,Richard;Nunez,Jill;He,Guo;Yan,Zhao;Jain,Rishi;Llamas,Luis;Luchansky,Sarah;Carlson,Adam;Liang,Guiqing;Kunjathoor,Vidya;Pietropaolo,Mike;Shapiro,Jeffrey;Castellana,Anja;Wu,Xiaoping;Bose,Avirup[ACSMedicinalChemistryLetters,2014,vol.5,#10,p.1114-1118]

[2]Peukert,Stefan;Hughes,Richard;Nunez,Jill;He,Guo;Yan,Zhao;Jain,Rishi;Llamas,Luis;Luchansky,Sarah;Carlson,Adam;Liang,Guiqing;Kunjathoor,Vidya;Pietropaolo,Mike;Shapiro,Jeffrey;Castellana,Anja;Wu,Xiaoping;Bose,Avirup[ACSMedicinalChemistryLetters,2014,vol.5,#10,p.1114-1118]

CASUnavailable 
 
CASUnavailable 
  1621175-65-2 

[1]Peukert,Stefan;Hughes,Richard;Nunez,Jill;He,Guo;Yan,Zhao;Jain,Rishi;Llamas,Luis;Luchansky,Sarah;Carlson,Adam;Liang,Guiqing;Kunjathoor,Vidya;Pietropaolo,Mike;Shapiro,Jeffrey;Castellana,Anja;Wu,Xiaoping;Bose,Avirup[ACSMedicinalChemistryLetters,2014,vol.5,#10,p.1114-1118]

Literature

Title: Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.

Journal: ACS medicinal chemistry letters 20141009

Title: Peukert S, et al. Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett. 2014 Aug 4;5(10):1114-8.

Title: Shimizu Y, et al. Rho kinase-dependent desensitization of GPR39; a unique mechanism of GPCR downregulation. Biochem Pharmacol. 2017 Sep 15;140:105-114.

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Tags:1621175-65-2 Molecular Formula|1621175-65-2 MDL|1621175-65-2 SMILES|1621175-65-2 N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide