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220119-17-5,MFCD09837837
Catalog No.:AA00BBKY

220119-17-5 | Selamectin

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1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$175.00   $122.00
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10mg
99% (HPLC)
in stock  
$258.00   $180.00
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25mg
≥98%
in stock  
$436.00   $305.00
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50mg
99% (HPLC)
in stock  
$761.00   $533.00
- +
100mg
97%
in stock  
$1,082.00   $758.00
- +
250mg
97%
in stock  
$2,365.00   $1,655.00
- +
500mg
99% (HPLC)
in stock  
$3,958.00   $2,771.00
- +
1000mg
99% (HPLC)
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BBKY
Chemical Name:
Selamectin
CAS Number:
220119-17-5
Molecular Formula:
C43H63NO11
Molecular Weight:
769.9604
MDL Number:
MFCD09837837
SMILES:
CO[C@H]1C[C@@H](O[C@H]([C@@H]1O)C)O[C@H]1[C@@H](C)/C=C/C=C/2\CO[C@H]3[C@]2(O)[C@@H](C=C(/C/3=N\O)C)C(=O)O[C@H]2C[C@@H](C/C=C/1\C)O[C@]1(C2)CC[C@@H]([C@H](O1)C1CCCCC1)C
Properties
Computed Properties
 
Complexity:
1550  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Defined Bond Stereocenter Count:
4  
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
5.4  

Literature

Title: Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer.

Journal: Molecular cancer therapeutics 20150801

Title: Safety and efficacy of spinosad chewable tablets for treatment of flea infestations of cats.

Journal: Journal of the American Veterinary Medical Association 20130415

Title: Efficacy of selamectin, spinosad, and spinosad/milbemycin oxime against the KS1 Ctenocephalides felis flea strain infesting dogs.

Journal: Parasites & vectors 20130101

Title: Comparison of efficacy, safety, and convenience of selamectin versus ivermectin for treatment of Trixacarus caviae mange in pet guinea pigs (Cavia porcellus).

Journal: Journal of the American Veterinary Medical Association 20121015

Title: Treatment and prevention of natural heartworm (Dirofilaria immitis) infections in red pandas (Ailurus fulgens) with selamectin and ivermectin.

Journal: Parasitology international 20120601

Title: A case of an apparent infestation by Proisotoma spp. springtails (Collembola: Isotomidae) in a cat.

Journal: Veterinary dermatology 20120401

Title: Pharmacokinetics, efficacy, and adverse effects of selamectin following topical administration in flea-infested rabbits.

Journal: American journal of veterinary research 20120401

Title: Evaluation of spinosad for the oral treatment and control of flea infestations on dogs in Europe.

Journal: The Veterinary record 20120101

Title: Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.

Journal: The Journal of biological chemistry 20111223

Title: Haemaphysalis concinna (Acari: Ixodida): persistent efficacy of selamectin in Angora rabbits under laboratory conditions.

Journal: Parasitology research 20110901

Title: An outbreak of Trixacarus caviae infestation in guinea pigs at an animal petting facility and an evaluation of the safety and suitable dose of selamectin treatment.

Journal: The Journal of parasitology 20110801

Title: Efficacy of a single dose of an otic ivermectin preparation or selamectin for the treatment of Otodectes cynotis infestation in naturally infected cats.

Journal: Journal of feline medicine and surgery 20110801

Title: Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats.

Journal: Parasites & vectors 20110101

Title: Preliminary findings on the efficacy of selamectin in the treatment of dogs naturally infected with Dirofilaria repens.

Journal: Acta veterinaria Hungarica 20101201

Title: [Field study on the treatment of the feline ear canker caused by Otodectes cynotis with selamectin (Stronghold®)].

Journal: Wiener klinische Wochenschrift 20101001

Title: Oral selamectin in the treatment of canine generalised demodicosis.

Journal: The Veterinary record 20100605

Title: Comparison of selamectin and imidacloprid plus permethrin in eliminating Leporacarus gibbus infestation in laboratory rabbits (Oryctolagus cuniculus).

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20091101

Title: The acute effects of single-dose orally administered doramectin, eprinomectin and selamectin on natural infections of Syphacia muris in rats.

Journal: Experimental parasitology 20090701

Title: Effectiveness of a selamectin spot-on formulation in rabbits with sarcoptic mange.

Journal: The Veterinary record 20090404

Title: Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice.

Journal: Journal of veterinary pharmacology and therapeutics 20090201

Title: Comparing therapeutic efficacy between ivermectin, selamectin, and moxidectin in canaries during natural infection with Dermanyssus gallinae.

Journal: Annals of the New York Academy of Sciences 20081201

Title: Flea blood feeding patterns in cats treated with oral nitenpyram and the topical insecticides imidacloprid, fipronil and selamectin.

Journal: Veterinary parasitology 20081001

Title: Comparison of efficacy of selamectin, ivermectin and mebendazole for the control of gastrointestinal nematodes in rhesus macaques, China.

Journal: Veterinary parasitology 20080506

Title: Use of selamectin and moxidectin in the treatment of mouse fur mites.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20080501

Title: Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits.

Journal: Veterinary dermatology 20080201

Title: Pneumonyssoides species infestation in two Pekingese dogs in the UK.

Journal: The Journal of small animal practice 20080201

Title: Treatment of rabbit cheyletiellosis with selamectin or ivermectin: a retrospective case study.

Journal: Acta veterinaria Scandinavica 20080101

Title: Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats.

Journal: Polish journal of veterinary sciences 20080101

Title: Use of topical selamectin for the treatment of Trichosomoides crassicauda infection in laboratory rats.

Journal: Polish journal of veterinary sciences 20080101

Title: Comparative efficacy of imidacloprid, selamectin, fipronil-(S)-methoprene, and metaflumizone against cats experimentally infested with Ctenocephalides felis.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats.

Journal: Acta veterinaria Scandinavica 20080101

Title: Plasma pharmacokinetics of selamectin after a single topical administration in the American bullfrog (Rana catesbeiana).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20070301

Title: Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits.

Journal: Veterinary dermatology 20070201

Title: Comparison of the activity of selamectin, imidacloprid and fipronil for the treatment of cats infested experimentally with Ctenocephalides felis felis and Ctenocephalides felis strongylus.

Journal: Veterinary parasitology 20070131

Title: Efficacy of selamectin and fipronil-(S)-methoprene spot-on formulations applied to cats against adult cat fleas (Ctenocephalides felis), flea eggs, and adult flea emergence.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Efficacy and safety of selamectin in the treatment of Otodectes cynotis infestation in domestic ferrets.

Journal: The Veterinary record 20061125

Title: Localised sarcoptic mange in dogs: a retrospective study of 10 cases.

Journal: The Journal of small animal practice 20061001

Title: Topical selamectin was 100% ineffective in eliminating Syphacia infections in rats and mice.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20060901

Title: Multimodal approach to treatment for control of fur mites.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20060701

Title: Efficacy and safety of topical selamectin to eradicate pinworm (Syphacia spp.) infections in rats (Rattus norvegicus) and mice (Mus musculus).

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20060501

Title: Efficacy of selamectin against mites (Myobia musculi, Mycoptes musculinus and Radfordia ensifera) and nematodes (Aspiculuris tetraptera and Syphacia obvelata) in mice.

Journal: Laboratory animals 20060401

Title: The efficacy of an imidacloprid/moxidectin combination against naturally acquired Sarcoptes scabiei infestations on dogs.

Journal: Australian veterinary journal 20060101

Title: Safety of imidacloprid plus moxidectin topical solution applied to cats heavily infected with adult heartworms (Dirofilaria immitis).

Journal: Parasitology research 20051001

Title: Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study.

Journal: Parasitology research 20051001

Title: Disposition of 3H-selamectin and 3H-ivermectin in the brain of the cat flea Ctenocephalides felis felis using micro-image analysis.

Journal: Veterinary parasitology 20050715

Title: Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein.

Journal: Journal of veterinary pharmacology and therapeutics 20050601

Title: Clinical efficacy of selamectin in the treatment of naturally acquired infection of sucking lice (Linognathus setosus) in dogs.

Journal: Journal of the American Animal Hospital Association 20050101

Title: Comparative speed of kill of selamectin, imidacloprid, and fipronil-(S)-methoprene spot-on formulations against fleas on cats.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Preventing parasites in cats.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Pharmacokinetics of selamectin in dogs after topical application.

Journal: Veterinary research communications 20040701

Title: Current trends in the treatment of Sarcoptes, Cheyletiella and Otodectes mite infestations in dogs and cats.

Journal: Veterinary dermatology 20040401

Title: Treatment of Notoedres cati infestation in cats with selamectin.

Journal: The Veterinary record 20040327

Title: Efficacy of selamectin in the treatment of nasal mite (Pneumonyssoides caninum) infection in dogs.

Journal: Journal of the American Animal Hospital Association 20040101

Title: Chloride channels as tools for developing selective insecticides.

Journal: Archives of insect biochemistry and physiology 20031201

Title: Use of near-infrared spectrometry for quantitative determinations of selamectin and moisture in topical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20030915

Title: Efficacy of selamectin in the treatment and control of clinical signs of flea allergy dermatitis in dogs and cats experimentally infested with fleas.

Journal: Journal of the American Veterinary Medical Association 20030901

Title: Comparison of the activity of selamectin, fipronil, and imidacloprid against flea larvae (Ctenocephalides felis felis) in vitro.

Journal: Veterinary parasitology 20030829

Title: Efficacy and safety of topical administration of selamectin for treatment of ear mite infestation in rabbits.

Journal: Journal of the American Veterinary Medical Association 20030801

Title: Two cases of cutaneous nodular dirofilariasis in the cat.

Journal: The Journal of small animal practice 20030701

Title: Evaluation of the efficacy of an imidacloprid 10%/moxidectin 2.5% spot-on against Sarcoptes scabieivar canison dogs.

Journal: Parasitology research 20030701

Title: Efficacy of selamectin administered topically in the treatment of feline otoacariosis.

Journal: Veterinary parasitology 20030310

Title: Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs.

Journal: Veterinary parasitology 20030310

Title: Efficacy of selamectin against biting lice on dogs and cats.

Journal: The Veterinary record 20030222

Title: Efficacy of selamectin in the treatment of canine cheyletiellosis.

Journal: The Veterinary record 20021201

Title: Efficacy of selamectin in the treatment of naturally acquired cheyletiellosis in cats.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20021001

Title: Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20020801

Title: Evaluation of the comparative efficacy of selamectin against flea (Ctenocephalides felis felis) infestations on dogs and cats in simulated home environments.

Journal: Veterinary parasitology 20020603

Title: Toxicology of newer pesticides for use in dogs and cats.

Journal: The Veterinary clinics of North America. Small animal practice 20020301

Title: Gasterophilus in dogs.

Journal: The Veterinary record 20020209

Title: Repellency and efficacy of 65% permethrin and selamectin spot-on formulations against Ixodes ricinus ticks on dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Comparison of the activity of selamectin, imidacloprid and fipronil for the treatment of dogs infested experimentally with Ctenocephalides canis and Ctenocephalides felis felis.

Journal: The Veterinary record 20011208

Title: Comparison of ivermectin, doramectin, selamectin, and eleven intermediates in a nematode larval development assay.

Journal: The Journal of parasitology 20010601

Title: Biotransformation of selamectin with Streptomyces lydicus SX-1298 using a novel static agar fermentation system with Reemay mesh.

Journal: The Journal of antibiotics 20010501

Title: Comparative study on the effects of three insecticides (fipronil, imidacloprid, selamectin) on developmental stages of the cat flea (Ctenocephalides felis Bouché 1835): a light and electron microscopic analysis of in vivo and in vitro experiments.

Journal: Parasitology research 20010301

Title: Determination of selamectin in dog plasma by high performance liquid chromatography with automated solid phase extraction and fluorescence detection.

Journal: Veterinary research 20010101

Title: Patsharaporn T Sarasombath, et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions. Parasitol Res. 2019 Apr;118(4):1289-1297.

Title: J Griffin, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther. 2005 Jun;28(3):257-65.

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