241479-67-4,MFCD06407745
Catalog No.:AA00BBLN

241479-67-4 | Isavuconazole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$20.00   $14.00
- +
1g
98%
in stock  
$65.00   $46.00
- +
5g
98%
in stock  
$192.00   $135.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BBLN
Chemical Name:
Isavuconazole
CAS Number:
241479-67-4
Molecular Formula:
C22H17F2N5OS
Molecular Weight:
437.4651
MDL Number:
MFCD06407745
SMILES:
N#Cc1ccc(cc1)c1csc(n1)[C@@H]([C@@](c1cc(F)ccc1F)(Cn1cncn1)O)C
Properties
Computed Properties
 
Complexity:
657  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Literature

Title: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20151115

Title: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent.

Journal: Pharmacotherapy 20151101

Title: Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility.

Journal: Journal of clinical microbiology 20130901

Title: Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections.

Journal: Expert opinion on drug metabolism & toxicology 20120601

Title: Simultaneous determination of the azoles voriconazole, posaconazole, isavuconazole, itraconazole and its metabolite hydroxy-itraconazole in human plasma by reversed phase ultra-performance liquid chromatography with ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301

Title: Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.

Journal: The Journal of antimicrobial chemotherapy 20120201

Title: Safety and efficacy of liposomal amphotericin B for the empirical therapy of invasive fungal infections in immunocompromised patients.

Journal: Infection and drug resistance 20120101

Title: Resistance of Asian Cryptococcus neoformans serotype A is confined to few microsatellite genotypes.

Journal: PloS one 20120101

Title: In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing.

Journal: Diagnostic microbiology and infectious disease 20111201

Title: Microdilution in vitro antifungal susceptibility of Exophiala dermatitidis, a systemic opportunist.

Journal: Medical mycology 20111101

Title: In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs.

Journal: Mycoses 20110901

Title: Newer antifungal agents.

Journal: Expert review of anti-infective therapy 20110301

Title: Antifungal activity of redox-active benzaldehydes that target cellular antioxidation.

Journal: Annals of clinical microbiology and antimicrobials 20110101

Title: Epidemiology and treatment approaches in management of invasive fungal infections.

Journal: Clinical epidemiology 20110101

Title: In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates.

Journal: Antimicrobial agents and chemotherapy 20101201

Title: Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain.

Journal: Medical mycology 20101101

Title: Isavuconazole: a comprehensive review of spectrum of activity of a new triazole.

Journal: Mycopathologia 20101101

Title: In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

Journal: International journal of antimicrobial agents 20101001

Title: Chromatographic and electrophoretic techniques used in the analysis of triazole antifungal agents-a review.

Journal: Talanta 20100915

Title: In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens.

Journal: Antimicrobial agents and chemotherapy 20100901

Title: Opportunistic fungi: a view to the future.

Journal: The American journal of the medical sciences 20100901

Title: Rhinocladiella aquaspersa, proven agent of verrucous skin infection and a novel type of chromoblastomycosis.

Journal: Medical mycology 20100801

Title: [Recent advances in the study of new antifungal lead compounds].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100801

Title: In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp.

Journal: Antimicrobial agents and chemotherapy 20100401

Title: Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.

Journal: Current opinion in investigational drugs (London, England : 2000) 20100201

Title: Microsatellite typing and susceptibilities of serial Cryptococcus neoformans isolates from Cuban patients with recurrent cryptococcal meningitis.

Journal: BMC infectious diseases 20100101

Title: Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections.

Journal: Drug, healthcare and patient safety 20100101

Title: Comparison of adverse events between oral and intravenous formulations of antimicrobial agents: a systematic review of the evidence from randomized trials.

Journal: Pharmacoepidemiology and drug safety 20091001

Title: New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance.

Journal: Expert review of anti-infective therapy 20091001

Title: New generation azole antifungals in clinical investigation.

Journal: Expert opinion on investigational drugs 20090901

Title: In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species.

Journal: The Journal of antimicrobial chemotherapy 20090701

Title: In vitro antifungal activity of isavuconazole against 345 mucorales isolates collected at study centers in eight countries.

Journal: Journal of chemotherapy (Florence, Italy) 20090601

Title: In vitro activities of isavuconazole against opportunistic filamentous and dimorphic fungi.

Journal: Medical mycology 20090201

Title: Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans.

Journal: Antimicrobial agents and chemotherapy 20090101

Title: Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei.

Journal: The Journal of antimicrobial chemotherapy 20090101

Title: Cryptococcus gattii: An Emerging Cause of Fungal Disease in North America.

Journal: Interdisciplinary perspectives on infectious diseases 20090101

Title: Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections.

Journal: Future microbiology 20081201

Title: New and investigational triazole agents for the treatment of invasive fungal infections.

Journal: Journal of chemotherapy (Florence, Italy) 20081201

Title: Investigational antimicrobial drugs for bloodstream infections.

Journal: Current opinion in investigational drugs (London, England : 2000) 20080801

Title: New and emerging treatments for fungal infections.

Journal: The Journal of antimicrobial chemotherapy 20080101

Title: Drug evaluation: BAL-8557--a novel broad-spectrum triazole antifungal.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060801

Title: In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp.

Journal: The Journal of antimicrobial chemotherapy 20060101

Title: Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers.

Journal: Antimicrobial agents and chemotherapy 20060101

Title: Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers.

Journal: Antimicrobial agents and chemotherapy 20060101

Title: Seifert H, et al. In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. Antimicrob Agents Chemother. 2007 May;51(5):1818-21.

Title: Steinmann J, et al. In Vitro Activity of Isavuconazole against Rasamsonia Species. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6890-6891.

Title: Donnelley MA, et al. Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections. Infect Drug Resist. 2016 Jun 2;9:79-86.

Title: Box H, et al. Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):278-87.

Title: Livermore J, et al. Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):759-65.

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Tags:241479-67-4 Molecular Formula|241479-67-4 MDL|241479-67-4 SMILES|241479-67-4 Isavuconazole
Catalog No.: AA00BBLN
241479-67-4,MFCD06407745
241479-67-4 | Isavuconazole
Pack Size: 100mg
Purity: 98%
in stock
$20.00 $14.00
Pack Size: 1g
Purity: 98%
in stock
$65.00 $46.00
Pack Size: 5g
Purity: 98%
in stock
$192.00 $135.00
Quantity
- +
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Technical Information
Catalog Number: AA00BBLN
Chemical Name: Isavuconazole
CAS Number: 241479-67-4
Molecular Formula: C22H17F2N5OS
Molecular Weight: 437.4651
MDL Number: MFCD06407745
SMILES: N#Cc1ccc(cc1)c1csc(n1)[C@@H]([C@@](c1cc(F)ccc1F)(Cn1cncn1)O)C
Properties
Complexity: 657  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Literature fold

Title: Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20151115

Title: Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent.

Journal: Pharmacotherapy20151101

Title: Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility.

Journal: Journal of clinical microbiology20130901

Title: Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections.

Journal: Expert opinion on drug metabolism & toxicology20120601

Title: Simultaneous determination of the azoles voriconazole, posaconazole, isavuconazole, itraconazole and its metabolite hydroxy-itraconazole in human plasma by reversed phase ultra-performance liquid chromatography with ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120301

Title: Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.

Journal: The Journal of antimicrobial chemotherapy20120201

Title: Safety and efficacy of liposomal amphotericin B for the empirical therapy of invasive fungal infections in immunocompromised patients.

Journal: Infection and drug resistance20120101

Title: Resistance of Asian Cryptococcus neoformans serotype A is confined to few microsatellite genotypes.

Journal: PloS one20120101

Title: In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing.

Journal: Diagnostic microbiology and infectious disease20111201

Title: Microdilution in vitro antifungal susceptibility of Exophiala dermatitidis, a systemic opportunist.

Journal: Medical mycology20111101

Title: In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs.

Journal: Mycoses20110901

Title: Newer antifungal agents.

Journal: Expert review of anti-infective therapy20110301

Title: Antifungal activity of redox-active benzaldehydes that target cellular antioxidation.

Journal: Annals of clinical microbiology and antimicrobials20110101

Title: Epidemiology and treatment approaches in management of invasive fungal infections.

Journal: Clinical epidemiology20110101

Title: In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates.

Journal: Antimicrobial agents and chemotherapy20101201

Title: Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain.

Journal: Medical mycology20101101

Title: Isavuconazole: a comprehensive review of spectrum of activity of a new triazole.

Journal: Mycopathologia20101101

Title: In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.

Journal: International journal of antimicrobial agents20101001

Title: Chromatographic and electrophoretic techniques used in the analysis of triazole antifungal agents-a review.

Journal: Talanta20100915

Title: In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens.

Journal: Antimicrobial agents and chemotherapy20100901

Title: Opportunistic fungi: a view to the future.

Journal: The American journal of the medical sciences20100901

Title: Rhinocladiella aquaspersa, proven agent of verrucous skin infection and a novel type of chromoblastomycosis.

Journal: Medical mycology20100801

Title: [Recent advances in the study of new antifungal lead compounds].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20100801

Title: In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp.

Journal: Antimicrobial agents and chemotherapy20100401

Title: Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.

Journal: Current opinion in investigational drugs (London, England : 2000)20100201

Title: Microsatellite typing and susceptibilities of serial Cryptococcus neoformans isolates from Cuban patients with recurrent cryptococcal meningitis.

Journal: BMC infectious diseases20100101

Title: Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections.

Journal: Drug, healthcare and patient safety20100101

Title: Comparison of adverse events between oral and intravenous formulations of antimicrobial agents: a systematic review of the evidence from randomized trials.

Journal: Pharmacoepidemiology and drug safety20091001

Title: New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance.

Journal: Expert review of anti-infective therapy20091001

Title: New generation azole antifungals in clinical investigation.

Journal: Expert opinion on investigational drugs20090901

Title: In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species.

Journal: The Journal of antimicrobial chemotherapy20090701

Title: In vitro antifungal activity of isavuconazole against 345 mucorales isolates collected at study centers in eight countries.

Journal: Journal of chemotherapy (Florence, Italy)20090601

Title: In vitro activities of isavuconazole against opportunistic filamentous and dimorphic fungi.

Journal: Medical mycology20090201

Title: Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans.

Journal: Antimicrobial agents and chemotherapy20090101

Title: Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei.

Journal: The Journal of antimicrobial chemotherapy20090101

Title: Cryptococcus gattii: An Emerging Cause of Fungal Disease in North America.

Journal: Interdisciplinary perspectives on infectious diseases20090101

Title: Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections.

Journal: Future microbiology20081201

Title: New and investigational triazole agents for the treatment of invasive fungal infections.

Journal: Journal of chemotherapy (Florence, Italy)20081201

Title: Investigational antimicrobial drugs for bloodstream infections.

Journal: Current opinion in investigational drugs (London, England : 2000)20080801

Title: New and emerging treatments for fungal infections.

Journal: The Journal of antimicrobial chemotherapy20080101

Title: Drug evaluation: BAL-8557--a novel broad-spectrum triazole antifungal.

Journal: Current opinion in investigational drugs (London, England : 2000)20060801

Title: In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp.

Journal: The Journal of antimicrobial chemotherapy20060101

Title: Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers.

Journal: Antimicrobial agents and chemotherapy20060101

Title: Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers.

Journal: Antimicrobial agents and chemotherapy20060101

Title: Seifert H, et al. In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. Antimicrob Agents Chemother. 2007 May;51(5):1818-21.

Title: Steinmann J, et al. In Vitro Activity of Isavuconazole against Rasamsonia Species. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6890-6891.

Title: Donnelley MA, et al. Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections. Infect Drug Resist. 2016 Jun 2;9:79-86.

Title: Box H, et al. Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):278-87.

Title: Livermore J, et al. Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):759-65.

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