Title: New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors.
Journal: Current treatment options in neurology 20120201
Title: Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis.
Journal: Clinical and experimental rheumatology 20120101
Title: Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase.
Journal: Molecular and cellular biochemistry 20111201
Title: Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
Journal: Bioorganic & medicinal chemistry letters 20110715
Title: Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20110515
Title: Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease.
Journal: Free radical biology & medicine 20110301
Title: Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache.
Journal: Cephalalgia : an international journal of headache 20101201
Title: Inhibition of inducible nitric oxide synthase in respiratory diseases.
Journal: Biochemical Society transactions 20090801
Title: Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma.
Journal: American journal of respiratory and critical care medicine 20071115
Title: y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages.
Journal: Amino acids 20060901
Title: An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
Journal: European journal of pain (London, England) 20060801
Title: Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock.
Journal: Critical care medicine 20060201
Title: GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.
Journal: Pain 20060101
Title: GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.
Journal: British journal of pharmacology 20050601
Title: Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acid.
Journal: European journal of pharmacology 20050110
Title: Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury.
Journal: Respiratory research 20050101
Title: 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Journal: Journal of medicinal chemistry 20040603
Title: Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation.
Journal: British journal of pharmacology 20040301
Title: GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cells.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20031001
Title: GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury.
Journal: Kidney international 20030301
Title: A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201
Title: Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis.
Journal: European journal of pharmacology 20021018
Title: NOS-II is involved in early differentiation of murine cortical, retinal and ES cell-derived neurons-an immunocytochemical and functional approach.
Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20020401
Title: Nitric oxide synthases: structure, function and inhibition.
Journal: The Biochemical journal 20010801
Title: Inhibitors of nitric oxide synthase in inflammatory arthritis.
Journal: IDrugs : the investigational drugs journal 19980701
Title: Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145(3):301-12.
Title: Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141(6):979-87. Epub 2004 Feb
Title: Broom L, et al. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease.Free Radic Biol Med. 2011 Mar 1;50(5):633-40.
