Home Imidazoles 2784-27-2
2784-27-2,MFCD00005262
Catalog No.:AA00BCVP

2784-27-2 | 5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione

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250mg
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1g
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5g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BCVP
Chemical Name:
5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione
CAS Number:
2784-27-2
Molecular Formula:
C15H12N2O3
Molecular Weight:
268.2674
MDL Number:
MFCD00005262
SMILES:
O=C1NC(=O)C(N1)(c1ccc(cc1)O)c1ccccc1
NSC Number:
156081
Properties
Properties
 
Form:
Solid  
MP:
>300°C  
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
398  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.1  

Downstream Synthesis Route
2784-27-2   
5-(3,5-dibromo-4-hydroxy-phenyl)-5-phenyl-imidazolidine-2,4-dione 

[1]Melton;Henze[JournaloftheAmericanChemicalSociety,1947,vol.69,p.2018]

2784-27-2   
5-(4-hydroxy-3,5-diiodo-phenyl)-5-phenyl-imidazolidine-2,4-dione 

[1]Melton;Henze[JournaloftheAmericanChemicalSociety,1947,vol.69,p.2018]

[1]Nitzetal.[Arzneimittel-Forschung/DrugResearch,1955,vol.5,p.357,358]

[1]Moustafa;El-Emam;Subbagh;SharafEl-Din[Arzneimittel-Forschung/DrugResearch,1990,vol.40,#10,p.1076-1078]

[1]Eto;Noda;Minemoto;Noda[ChemicalandPharmaceuticalBulletin,1988,vol.36,#1,p.456-458]

[2]Kasuya;Mamada;Baba;Matsukura[JournalofPharmaceuticalSciences,1985,vol.74,#5,p.503-507]

Literature

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Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120201

Title: Validated HPLC Method for Concurrent Determination of Antipyrine, Carbamazepine, Furosemide and Phenytoin and its Application in Assessment of Drug Permeability through Caco-2 Cell Monolayers.

Journal: Scientia pharmaceutica 20120101

Title: Characterization of interaction kinetics between chiral solutes and human serum albumin by using high-performance affinity chromatography and peak profiling.

Journal: Journal of chromatography. A 20110928

Title: Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201

Title: Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy.

Journal: Therapeutic drug monitoring 20110201

Title: Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features.

Journal: ISRN dentistry 20110101

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Journal: Journal of inflammation (London, England) 20100101

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Journal: The Journal of pharmacology and experimental therapeutics 20090601

Title: Determination of phenytoin and its major metabolite in human serum by MEKC.

Journal: Journal of chromatographic science 20090101

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Journal: Journal of endourology 20080801

Title: Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.

Journal: European journal of clinical pharmacology 20080401

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Journal: Biopharmaceutics & drug disposition 20080101

Title: High-performance liquid chromatographic method for determination of phenytoin in rabbits receiving sildenafil.

Journal: Analytical chemistry insights 20080101

Title: Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070901

Title: CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201

Title: Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.

Journal: Epilepsy research 20060901

Title: Studies by biointeraction chromatography of binding by phenytoin metabolites to human serum albumin.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060519

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.

Journal: The Indian journal of medical research 20060501

Title: CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population.

Journal: Pharmacogenetics and genomics 20051101

Title: Analytic performance evaluation of a new turbidimetric immunoassay for phenytoin on the ADVIA 1650 analyzer: effect of phenytoin metabolite and analogue.

Journal: Therapeutic drug monitoring 20050601

Title: Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases.

Journal: Drug metabolism and pharmacokinetics 20050401

Title: The effects of phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin on cellular glucose transport.

Journal: Life sciences 20050304

Title: Phenytoin overview--metabolite interference in some immunoassays could be clinically important.

Journal: Archives of pathology & laboratory medicine 20040701

Title: Key structural features of ligands for activation of human pregnane X receptor.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040401

Title: The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.

Journal: Pharmaceutical research 20031001

Title: Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021101

Title: Modeling and kinetic analysis of the reaction system using whole cells with separately and co-expressed D-hydantoinase and N-carbamoylase.

Journal: Biotechnology and bioengineering 20020630

Title: Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes.

Journal: Biochemical pharmacology 20020615

Title: Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020601

Title: Effects of cysteine on the pharmacokinetics of intravenous phenytoin in rats with protein-calorie malnutrition.

Journal: International journal of pharmaceutics 20011023

Title: Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo.

Journal: Pharmacogenetics 20011001

Title: Effect of mild therapeutic hypothermia on phenytoin pharmacokinetics.

Journal: Therapeutic drug monitoring 20010601

Title: Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors.

Journal: Epilepsy research 20010401

Title: Stereoselective determination of p-hydroxyphenyl-phenylhydantoin enantiomers in rat liver microsomal incubates by reversed-phase high-performance liquid chromatography using beta-cyclodextrin as chiral mobile phase additives.

Journal: Biomedical chromatography : BMC 20010401

Title: Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.

Journal: British journal of clinical pharmacology 19970401

Title: Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19940101

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Tags:2784-27-2 Molecular Formula|2784-27-2 MDL|2784-27-2 SMILES|2784-27-2 5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione