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20931-37-7,MFCD00951751
Catalog No.:AA00BE34

20931-37-7 | Beta-mangostin

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1mg
≥95%
in stock  
$346.00   $242.00
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5mg
≥95%
in stock  
$1,379.00   $965.00
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10mg
≥95%
in stock  
$2,069.00   $1,448.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BE34
Chemical Name:
Beta-mangostin
CAS Number:
20931-37-7
Molecular Formula:
C25H28O6
Molecular Weight:
424.4862
MDL Number:
MFCD00951751
SMILES:
COc1c(O)cc2c(c1CC=C(C)C)c(=O)c1c(o2)cc(c(c1O)CC=C(C)C)OC
Properties
Computed Properties
 
Complexity:
692  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
6.6  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,p.2062-2065

[2]BioorganicandMedicinalChemistryLetters,2015,vol.25,p.5625-5631

[3]Patent:KR2015/122946,2015,A

20931-37-7    638-45-9   
6-O-hexyl-β-mangostin 

[1]Karunakaran,Thiruventhan;Ee,GwendolineChengLian;Ismail,IntanSafinar;MohdNor,SitiMariam;Zamakshshari,NorHisam[NaturalProductResearch,2017,p.1-5]

Literature

Title: Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.

Journal: Bioorganic & medicinal chemistry letters 20101015

Title: Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).

Journal: Journal of natural products 20091101

Title: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

Journal: Bioorganic & medicinal chemistry 20080415

Title: Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.

Journal: Journal of natural products 20030801

Title: Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.

Journal: Chemical & pharmaceutical bulletin 20030701

Title: Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.

Journal: Journal of natural products 20030201

Title: Chien-Feng Huang, et al.β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. Environ Toxicol. 2017 Nov;32(11):2360-2370.

Title: Fatima Abdelmutaal Ahmed Omer, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest. Tumour Biol. 2017 Nov;39(11):1010428317731451.

Title: K Likhitwitayawuid, et al. Antimalarial xanthones from Garcinia cowa. Planta Med. 1998 Feb;64(1):70-2.

Title: Sunit Suksamrarn, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9.

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SDS
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