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218137-86-1,MFCD03426157
Catalog No.:AA00BE60

218137-86-1 | 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

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1mg
95%
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$366.00   $257.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00BE60
Chemical Name:
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
CAS Number:
218137-86-1
Molecular Formula:
C14H22O4
Molecular Weight:
254.3221
MDL Number:
MFCD03426157
SMILES:
CCCCCCCCC1OC(=O)C(=C)C1C(=O)O
Properties
Computed Properties
 
Complexity:
322  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
2  
XLogP3:
4  

Literature

Title: Synthesis and biological activity of enantiomeric pairs of 5-[(E)-cycloalk-2-enylidenemethyl]thiolactomycin congeners.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.

Title: Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.

Title: Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

Title: Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

Title: Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.

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Tags:218137-86-1 Molecular Formula|218137-86-1 MDL|218137-86-1 SMILES|218137-86-1 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid