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24150-24-1,MFCD11113155
Catalog No.:AA00BE83

24150-24-1 | EM-1421

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50mg
≥95%
in stock  
$23.00   $16.00
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100mg
≥95%
in stock  
$40.00   $28.00
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500mg
≥95%
in stock  
$156.00   $109.00
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1g
≥95%
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$269.00   $188.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BE83
Chemical Name:
EM-1421
CAS Number:
24150-24-1
Molecular Formula:
C22H30O4
Molecular Weight:
358.4712
MDL Number:
MFCD11113155
SMILES:
COc1cc(ccc1OC)CC(C(Cc1ccc(c(c1)OC)OC)C)C
Properties
Computed Properties
 
Complexity:
352  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
5.6  

Literature

Title: Restraining the flexibility of the central linker in terameprocol results in constrained analogs with improved growth inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 20131115

Title: Phase I study of terameprocol in patients with recurrent high-grade glioma.

Journal: Neuro-oncology 20120401

Title: Significant biological role of sp1 transactivation in multiple myeloma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20111015

Title: Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling.

Journal: The Journal of pathology 20110301

Title: Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110101

Title: Glycosylated nordihydroguaiaretic acids as anti-cancer agents.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid.

Journal: Antiviral research 20101201

Title: Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.

Journal: Journal of natural products 20090601

Title: Phase I clinical trial of repeat dose terameprocol vaginal ointment in healthy female volunteers.

Journal: Sexually transmitted diseases 20080601

Title: New nordihydroguaiaretic acid derivatives as anti-HIV agents.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.

Journal: IDrugs : the investigational drugs journal 20080301

Title: Phase I/II clinical safety studies of terameprocol vaginal ointment.

Journal: Gynecologic oncology 20071201

Title: The anticancer activity of the transcription inhibitor terameprocol (meso-tetra-O-methyl nordihydroguaiaretic acid) formulated for systemic administration.

Journal: Anti-cancer drugs 20070901

Title: Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid.

Journal: Seminars in oncology 20060801

Title: Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050615

Title: CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target.

Journal: The American journal of surgical pathology 20050301

Title: Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.

Journal: Journal of medicinal chemistry 20020606

Title: tetra-O-methylnordihydroguaiaretic acid inhibits melanoma in vivo.

Journal: Cancer letters 20010928

Title: Johns Hopkins embroiled in fresh misconduct allegations.

Journal: Nature 20010802

Title: Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo.

Journal: Cancer research 20010715

Title: Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation.

Journal: Journal of medicinal chemistry 19980730

Title: Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA.

Journal: Journal of medicinal chemistry 19980730

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Tags:24150-24-1 Molecular Formula|24150-24-1 MDL|24150-24-1 SMILES|24150-24-1 EM-1421