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21715-46-8,MFCD00868190
Catalog No.:AA00BE8I

21715-46-8 | Etifoxine

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5mg
≥98%
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$123.00   $86.00
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10mg
≥98%
in stock  
$185.00   $129.00
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25mg
≥98%
in stock  
$423.00   $296.00
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50mg
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$657.00   $460.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BE8I
Chemical Name:
Etifoxine
CAS Number:
21715-46-8
Molecular Formula:
C17H17ClN2O
Molecular Weight:
300.7827
MDL Number:
MFCD00868190
SMILES:
CCNC1=Nc2ccc(cc2C(O1)(C)c1ccccc1)Cl
Properties
Computed Properties
 
Complexity:
394  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.1  

Literature

Title: Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile.

Journal: Journal of neuroendocrinology 20120101

Title: Axonal regeneration and neuroinflammation: roles for the translocator protein 18 kDa.

Journal: Journal of neuroendocrinology 20120101

Title: Progesterone synthesis in the nervous system: implications for myelination and myelin repair.

Journal: Frontiers in neuroscience 20120101

Title: In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives: Identification of target metabolites for equine doping control.

Journal: Drug testing and analysis 20111001

Title: Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits?

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20110601

Title: Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Progesterone prevents development of neuropathic pain in a rat model: Timing and duration of treatment are critical.

Journal: Journal of pain research 20110101

Title: Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress.

Journal: Frontiers in neuroscience 20110101

Title: Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.

Journal: Frontiers in neuroscience 20110101

Title: Neurosteroids as neuromodulators in the treatment of anxiety disorders.

Journal: Frontiers in endocrinology 20110101

Title: Role of neuroactive steroids in the peripheral nervous system.

Journal: Frontiers in endocrinology 20110101

Title: Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice.

Journal: Behavioural brain research 20100402

Title: Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.

Journal: The Journal of pharmacology and experimental therapeutics 20100301

Title: Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroids.

Journal: Pain 20091215

Title: Etifoxine (Stresam) for chemotherapy-induced pain?

Journal: Pain 20091215

Title: General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: applications and constraints.

Journal: Journal of separation science 20090901

Title: Preventive and curative effects of etifoxine in a rat model of brain oedema.

Journal: Clinical and experimental pharmacology & physiology 20090701

Title: The anxiolytic etifoxine protects against convulsant and anxiogenic aspects of the alcohol withdrawal syndrome in mice.

Journal: Alcohol (Fayetteville, N.Y.) 20090501

Title: Adjustment Disorder: epidemiology, diagnosis and treatment.

Journal: Clinical practice and epidemiology in mental health : CP & EMH 20090101

Title: [Lymphocytic colitis probably due to etifoxine. A case with relapse after reintroduction].

Journal: Therapie 20090101

Title: [Pathomorphosis of anxiety disorder in patients with intestinal dysbiosis].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

Title: Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.

Journal: Psychopharmacology 20080501

Title: [Etifoxine: a new look at the GABA receptor and anxiety].

Journal: L'Encephale 20080401

Title: Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats.

Journal: Brain research 20071212

Title: Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodents.

Journal: Neuroscience research 20060901

Title: Anxiolytics, hypnotics, and antidepressants dispensed to adolescents in a French region in 2002.

Journal: Pharmacoepidemiology and drug safety 20060701

Title: Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice.

Journal: Human psychopharmacology 20060401

Title: The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.

Journal: Pharmacology, biochemistry, and behavior 20051201

Title: Effects of etifoxine on stress-induced hyperthermia, freezing behavior and colonic motor activation in rats.

Journal: Physiology & behavior 20041015

Title: Effects of stress and etifoxine on pentobarbital-induced loss of righting reflex in Balb/cByJ and C57BL/6J mice.

Journal: Neuroscience letters 20031219

Title: [Etifoxine chlorhydrate-induced acute hepatitis].

Journal: Gastroenterologie clinique et biologique 20031101

Title: The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit.

Journal: Neuropharmacology 20030901

Title: Effects of etifoxine on ligand binding to GABA(A) receptors in rodents.

Journal: Neuroscience research 20021001

Title: A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected].

Journal: Fundamental & clinical pharmacology 20010601

Title: Functional modulation of gamma-aminobutyric acid(A) receptors by etifoxine and allopregnanolone in rodents.

Journal: Neuroscience letters 20010406

Title: Etifoxine: evaluation of its anticonvulsant profile in mice in comparison with sodium valproate, phenytoin and clobazam.

Journal: Arzneimittel-Forschung 19850101

Title: Verleye M, Dumas S, Heulard I, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70.

Title: Bourin M, Hascot M. Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. Behav Brain Res. 2010 Apr 2;208(2):352-8.

Title: Gee KW, Tran MB, Hogenkamp DJ, et al. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53.

Title: Aouad M, Charlet A, Rodeau JL, et al. Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroids. Pain. 2009 Dec 15;147(1-3):54-9.

Title: Girard C, Liu S, Cadepond F, et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10.

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